Once the entire E3 ubiquitin ligase complex is assembled, the ubiquitin molecule is transferred from a conserved cysteine residue in the Ubc protein to one... DD Zhang,SC Lo,S Zheng,... 被引量: 346发表: 0年 Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery...
The VHL gene product (pVHL) forms a multimeric complex with the elongin B and C, Cul2 and Rbx1 proteins (VCBCR complex), which is homologous to the SCF family of ubiquitin ligase complexes. The VCBCR complex binds HIF-1α and HIF-2α, transcription facto
TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2 (SCF
Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8 来自 国家科技图书文献中心 喜欢 0 阅读量: 42 作者:C Yu,H Mao,EJ Novitsky,X Tang,SD Rychnovsky,N Zheng,L Huang 摘要: The full enzymatic activity of the cullin-RING ubiquitin ligases (...
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways Genes Dev., 13 (1999), pp. 505-510 CrossrefView in ScopusGoogle Scholar 27 P.B Meluh, D Koshland Budding yeast centromere composition and assembly as revealed by in vivo cross-linking Genes...
(PAMPs)and virus. Based on the GeneChip results,a group of E3 ubiqnitin ligase complex whose function in innate anti.viral immune responses remain unsown attract our attention.As F-BOX protein is the key substrate recongnition component of this complex,we analyse F-BOX proteins’expression ...
The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory proteins such as p27Kip1, IκB, and β-catenin. We report the isolation of a CUL1 binding protein, p120CAND1. We found the majority of CUL1 is in a complex with CAND1 and ROC1 independent of SKP1 ...
MolecularCell,Vol.4,21–33,July,1999,Copyright©1999byCellPress SGT1EncodesanEssentialComponentoftheYeast KinetochoreAssemblyPathwayandaNovelSubunit oftheSCFUbiquitinLigaseComplex mutationsinanyoneofthemabolishtheCDEIII-binding activityofCBF3. SKP1wasidentifiedasahighcopysuppressorofa ctf13mutant,ctf13–30(Co...
Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1.###Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1MYPT1 phosphatase complex and the SCFTrCP E3 ubiquitin ligase.###-Arrestin regulation of ...
ARTICLE Received 2 Aug 2015 | Accepted 29 Oct 2015 | Published 3 Dec 2015 DOI: 10.1038/ncomms10053 OPEN Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8 Clinton Yu1,*, Haibin Mao2,*, Eric J. Novitsky3, Xiaobo Tang2, Scott D. ...