《Inhibition of microrna-138 enhances bone formation in multiple myeloma bonemarrow niche》是发表在Leukemia (2018) (IF=11.702) 上的一篇文章,在本文研究中,作者探讨了miR-138在骨髓瘤骨病中的作用,并评估了anti-miR-138寡核苷酸在骨髓瘤骨病中的可能作。研究发现,与健康对照相比,在多发性骨髓瘤病人的间充质...
刘澎涛博士Nature:单细胞RNA-seq新成果 9月29日,在国际顶级学术期刊《Nature》发表的一项研究中,来自英国威康信托基金会桑格研究所、香港中文大学、上海农科院、上海交通大学、剑桥大学和墨尔本大学等处的研究人员,通过对骨髓(BM)先天淋巴细胞(ILCs)进行单细胞RNA测序(scRNAseq),确定了不同的ILC前体细胞亚群,描述了不...
刘澎涛博士Nature:单细胞RNA-seq新成果 9月29日,在国际顶级学术期刊《Nature》发表的一项研究中,来自英国威康信托基金会桑格研究所、香港中文大学、上海农科院、上海交通大学、剑桥大学和墨尔本大学等处的研究人员,通过对骨髓(BM)先天淋巴细胞(ILCs)进行单细胞RNA测序(scRNAseq),确定了不同的ILC前体细胞亚群,描述了不...
李程研究组使用代表两种亚型的骨髓瘤细胞(近二倍体U266和近三倍体RPMI-8226)和正常B细胞(GM12878),对拷贝数变异(CNV)和三维基因组的关系展开研究。 《Inhibition of microrna-138 enhances bone formation in multiple myeloma bonemarrow niche》是发表在Leukemia (2018)(IF=11.702)上的一篇文章,在本文研究中,作...
(ref. 9). Despite recent advances1, 2 10, the cellular heterogeneity, developmental trajectory and signalling dependence of ILC progenitors remain incompletely understood. Here we report that single-cell RNA-sequencing (scRNAseq) of bone marrow (BM) progenitors revealed ILC precursor subsets, ...
RNA-Seq Based Transcriptome Analysis of Endothelial Differentiation of Bone Marrow Mesenchymal Stem CellsGene expressionEndothelial differentiationStem cellsEndothelial cellsObjective: The aim was to identify the change in gene expression between mesenchymal stem cells (MSCs) and induced endothelial cells (ECs...
Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are typically purified from the bone marrow using cell surface markers. Recent studies have identified significant cellular heterogeneities in the...
DATA_DIR=Path("../../data/")DATA_DIR.mkdir(parents=True,exist_ok=True)FILE_NAME=DATA_DIR/"bone_marrow.h5ad" 11.4.3 数据加载 adata = sc.read( filename=FILE_NAME, backup_url="https://figshare.com/ndownloader/files/35826944", ...
Composite transcriptome asse- mbly of RNA-Seq data in a sheep model for delayed bone healing. BMC Genomics, 2011, 12 :158. [8]Huang W, Has an Khatib. Comparison of transcriptomic landscapes of bovine embryos using RNA-Seq. BMC Genomics, 2010, 11 :711, http ://www.biomedcentral.com/...
和南京医科大学附属口腔医院Ping Zhang团队合作在《Cell Death & Disease volume》杂志发表题为”Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption”的研究论文,该研究本研究采用MeRIP-Seq、荧光素酶报告基因检测、meRIP等方法从RNA甲基化角度...