Cancer, DNA repair mechanisms, and resistance to chemotherapy. Fojo T. Journal of the National Cancer Institute . 2001Fojo T (2001) Cancer, DNA repair mechanisms, and resistance to chemotherapy. J Natl Cancer Inst 93:1434-1436Fojo, T. (2001) Cancer, DNA repair mechanisms, and resistance ...
Current approaches to overcome resistance are focused on combining PARP inhibition with other inhibitors of the DNA damage response, immune-checkpoint inhibition or targeted therapies. Targeting the acquired vulnerabilities of PARP inhibitor-resistant tumours might selectively kill unresponsive cancer cells. Pr...
Mechanisms of resistance to PARP inhibitors in cancer include ontarget drug-resistance variants50 and reactivation of DNA damage repair pathways, such as the reversion of BRCA2 mutations51,52. We investigated genetic resistance mechanisms to olaparib53 and niraparib54 in the Ewing sarcoma cell line...
there are many therapeutic regimens for resistant ovarian cancer, including some novel agents. However, the objective remission rate is still low, and the median survival time is less than 12 months due to complicated resistance mechanisms. In resistant ovarian cancer, the classical mechanisms of ...
(2010) DNA Repair–Based Mechanisms of Platinum Resistance in Epithelial Ovarian Cancer: From Bench to Bedside. Clinical Ovarian Cancer 3 , 29-35 /↵ ... S Lafarge,V Sylvain,M Ferrara,... - 《Oncogene》 被引量: 420发表: 2001年 The relationship of platinum resistance and ERCC1 protein ...
5-Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the knowledge of its mechanism of action, various treatment modalities have been developed over the past few decades to increase its anti-cancer activity. But drug resistance has greatly affected the clin...
As such, the concept of targeting DNA repair has been successfully developed in the last decade to a bona fide therapeutic strategy with poly (ADP-ribose) polymerase inhibitors (PARPi) to treat DNA repair deficient breast, ovarian, pancreatic, and prostate cancers[3-9]. These successes have ...
DNA damage repair, apoptosis, characteristics of cancer stem cells, immune evasion, and other crucial biological functions. Additionally, the review highlights the potential clinical significance of USP inhibitors as a means to counter drug resistance in cancer treatment. By inhibiting particular USP, ...
Immune checkpoint inhibitors (ICIs) have altered the treatment paradigm across a range of tumour types, including gastro-oesophageal cancers. For patients with any cancer type who respond, ICIs can confer long-term disease control and significantly impro
DNA damage response; drug resistance; DNA damage repair inhibitors; biomarkers 1. Introduction DNA and other biological molecules are susceptible to damage, but DNA damage can have much more complex consequences due to its function. Unlike other molecules, which are synthesized and degraded depending ...