近期,Journal of Pineal Research 刊登了华盛顿州立大学研究人员题为 Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans 的文章,该研究证明,受试者暴露于打破昼夜节律性的夜班后,对内源性和外源性 DNA 损伤的敏感性都有所提高,DNA 损伤加剧,且 DNA 修复...
DNA damageHEPATITIS B virusDNA repairGENE expression profilingMULTIPLE myelomaPOLY(ADP-ribose) polymeraseThe International Journal of Molecular Sciences has published a Special Issue titled "DNA Damage, DNA Repair, and Cancer: Second Edition." The issue explores the topic of DNA damage and re...
DNA Damage, DNA Repair and Cancer 417 http://dx.doi.org/10.5772/53919 DNA damages Reported rate of occurrence 86,000 per cell per day in rats Ref. [18] Oxidative 10,000 per cell per day in humans 100,000 per cell per day in rats [19] 11,500 per cell per day for humans 74,...
Marc-Olivier Turgeon, et al. DNA Damage, Repair, and Cancer Metabolism. Front Oncol. 2018 Feb 5;8:15. Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christman...
The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis? Cancer InvestigationEastman A and Barry MA: The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis? Cancer Invest 10, 229-... A Eastman,MA Barry - 《Cancer Investigation》 被引量...
14.Müller A, Fishel R. 2002. Mismatch Repair and the Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC). Cancer Investigation. 20(1):102-109. 15.Lindahl T. 1974. An N-Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues. ...
Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored. In this review, we examine the evidence connecting DNA damage and repair mechanisms with cell met...
研究提出的“i-CRISPR”策略,就是根据癌细胞的DNA序列,定制且导入仅能切割癌细胞DNA的CRISPR-Cas9系统——“癌细胞CRISPR剪刀”,造成癌细胞中DNA断裂;同时添加DNA损伤修复抑制剂(DNA damage repair inhibitor, DSBRi),使癌细胞中断裂的DNA无法修复,导致细胞死亡。DNA损伤修复抑制剂就是“i-CIRSPR”策略中的“i”,...
近日,北京大学郑晓峰课题组在 Cancer Research 期刊发表了题为:SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer 的研究论文。该研究发现,去SUMO化酶SENP1应答DNA双链断裂损伤被招募到损伤位点,通过去除RNF168的SUMO化修饰来破坏其诱导的RNF168的液-液相...