1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 封面图来源:pixabay 版权声明/免责声明 本文为授权转载文章。 本文仅作信息交流之目的,不提供任何商用、医用、投资用建议。 文中图片、视频、字...
Alot of research is being performed on the modulation of DNA repair and its exploitation as a therapeutic principle to enhance the effects of chemotherapy. This paper outlines chemotherapy-induced DNA damage, its repair, consequences and the current state of DNA repair inhibitor development.D.C. ...
1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 公众号内回复“肿瘤免疫”或扫描下方图片中的二维码免费下载《小药说药肿瘤免疫全集》的PDF格式电子书! 公众号已建立“小药说药专业交流群”微信行业交流群以及读者交流群,扫描下方小编...
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DNA Damage Response and DNA Repair in Cancer AI-generated audio 25:41The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer ...
2024年1月10日,意大利斯维泽拉大学生物医学研究所Silvia Monticelli与Petr Cejka教授共同在国际知名期刊《Nature》发表了题为:DNA sensing and repair team up against cancer的论文。 细胞DNA通常存在于细胞核中,细胞核外的细胞质DNA十分少见。细胞质中的DNA能够作为一种异常信号调控细胞生命活动,例如发生病毒感染或癌症...
此外,对每一种肿瘤进行表征,以确定其失控的DDR成分的具体特征,将有助于癌症患者的个性化治疗。 参考文献: 1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 更多生物制药知识尽在微信公众号...
Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation...
36.Madhusudan S, Hickson ID. 2005. DNA repair inhibition: a selective tumour targeting strategy. Trends in Molecular Medicine. 11(11):503-511.37.PLUMMER E. 2006. Inhibition of poly(ADP-ribose) polymerase in cancer. Current Opinion in Pharmacology. 6(4):364-368.38.SABHARWAL A, MIDDLETON M...
近日,美国洛克菲勒大学Agata Smogorzewska研究组在Nature上发表了文章Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer,通过对FA鳞状细胞癌患者的基因组和外显子组进行测序,发现FA修复途径的缺陷会导致基因组存在大量的结构变异,且FA途径...