Cancer immunotherapyMicrosatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins ...
Colorectal cancer (CRC) remains one of the major causes of cancer death worldwide. Chemotherapy continues to serve as the primary treatment modality, while immunotherapy is largely ineffective for the majority of CRC patients. Seminal discoveries have emphasized that modifying DNA damage response (DDR)...
M. DNA mismatch repair in cancer immunotherapy. NAR Cancer 5, zcad031 (2023). Article PubMed PubMed Central Google Scholar Jeggo, P. A. & Löbrich, M. DNA double-strand breaks: their cellular and clinical impact? Oncogene 26, 7717–7719 (2007). Article CAS PubMed Google Scholar ...
The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside Darleny Y. Lizardo, ... Lin Zhang, in Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020 2.1 DNA mismatch repair system Complex organisms have developed robust mechanisms to maintain genomic stab...
DNA damage and repair biomarkers of immunotherapy response[J]. Cancer Discov, 2017, 7(7): 675-693. [4] Arjumand W, Asiaf A, Ahmad S T. Noncoding RNAs in DNA damage response: opportunities ...
Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision making. The present study aimed to develop and validate a deep learning (DL) model based on the pre-treatment CT images for predicting MMR status in CRC. Meth...
北京时间2020年12月18日凌晨0时,国际顶尖肿瘤学期刊Cancer Cell在线发表了美国西南医学中心傅阳心教授团队和李国民教授团队背靠背的两篇论文: DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-...
DNA damage repair and cancer immunotherapy Zhiyuan Xiang Hao Liu Ying Hu Genome Instability & Disease (2023) MSINGB: A Novel Computational Method Based on NGBoost for Identifying Microsatellite Instability Status from Tumor Mutation Annotation Data Jinxiang Chen Miao Wang Shuqin Li Interdisciplinary...
LUCHINI C, BIBEAU F, LIGTENBERG M J L, et al. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach[J]. Ann Oncol, 2019, 30(8): 1232-1243. ...