错配修复:错配修复(mismatchrepair):在含有错配碱基的DNA分子中,使正常核苷酸序列恢复的修复方式。这种修复方式的过程是:识别出下正确地链,切除掉不正确链的部分,然后通过DNA聚合酶和DNA连接酶的作用,合成正确配对的双链DNA。相关知识点: 试题来源: 解析 在大肠杆菌中,DNA连接酶催化的反应需要NAD+作为电子供体。
错配修复可校正DNA复制和重组过程中非同源染色体偶尔出现的DNA碱基错配，错配的碱基可被错配修复酶识别后进行修复。
DNA mismatch repair (MMR) plays a critical role in ensuring the fidelity of DNA replication. Errors during DNA synthesis, if uncorrected, give rise to mutations in the next round of replication. MMR targets these errors resulting in excision of misincorporated bases in the newly synthesized DNA ...
Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic...
Mismatch repair (MMR) is a single-strand repairing system for recognition and reversion of loops (insertion or deletion) and mismatches in DNA bases. From: Clinical Immunology, 2021 About this pageAdd to MendeleySet alert Also in subject areas: Agricultural and Biological Sciences Biochemistry, Gene...
DNA错配修复(DNA-Mismatch repair):在DNA复制时期来修复发生错配的DNA链。DNA错配修复系统可以识别合成链中的新链,因为新合成链没有甲基化,而亲本链被甲基化。一条链甲基化,另一条链没有甲基化,这样的双链DNA分子被成为半甲基化DNA。DNA的甲基化是因为dam甲基化酶可以使腺苷酸碱基甲基化。错配修复系统能够从...
Lynch综合征与错配修复基因MLH1,MSH2,MSH6和PMS2胚系突变相关,错配修复蛋白能够在DNA复制过程中修复单个碱基错配和插入缺失环,对于维持基因组稳定性起重要作用,而错配修复基因突变会导致高水平微卫星不稳定性(high level of microsatellite instability, MSI-H),使突变积累,最终导致肿瘤发生。错配修复蛋白是异二聚体...
林奇综合征(Lynch syndrome, LS)曾被称为遗传性非息肉病性结直肠癌(HNPCC), 是一种显性遗传性癌症综合征, 由细胞错配修复(mismatch repair, MMR )基因的可遗传突变引起, 表现为易患结直肠癌、子宫内膜癌、卵巢癌、胃癌、小肠癌...
mmrdna修复mismatchrepairhongshao DNA错配修复(DNAmismatchrepair, MMR) HongSHAO,等应用多重连接探针扩增法简便高效检测Prader—Willi综合征的基 因缺失?67? sive,andthecombinationofusingthesetestswillbe verycost.expensive.Althoughthesegenetictestshave beenapartofthestandardofhealthcareinthedevel? opedcountries.iti...