DNA mismatch repair (MMR) plays a critical role in ensuring the fidelity of DNA replication. Errors during DNA synthesis, if uncorrected, give rise to mutations in the next round of replication. MMR targets these errors resulting in excision of misincorporated bases in the newly synthesized DNA ...
replication, might minimize the need formismatch DNA repairin mammalian mitochondria[80]. However, that does not explain why budding yeast mitochondria have canonical mitochondrial MMR, despite having similar POLG proofreading activity. Historically, first mtDNA mutators were isolated in yeast and mapped...
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous rec...
林奇综合征(Lynch syndrome, LS)曾被称为遗传性非息肉病性结直肠癌(HNPCC), 是一种显性遗传性癌症综合征, 由细胞错配修复(mismatch repair, MMR )基因的可遗传突变引起, 表现为易患结直肠癌、子宫内膜癌、卵巢癌、胃癌、小肠癌...
DNA mismatch repair (MMR) recognizes and repairs erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, and repair some forms of DNA damage. It plays an important role in maintaining genomic stability and cellular homeostasis. For example...
Mismatch repair systems enhance the fidelity of DNA replication by correcting replicative errors skipped by the DNA polymerase during editing. Mutants defective in mismatch repair enzymes are marked by genome instability and/or mutator phenotypes (31). During homologous genetic recombination, mismatch ...
Despite the cytopathic nature of influenza A virus (IAV) replication, we recently reported that a subset of lung epithelial club cells is able to intrinsically clear the virus and survive infection. However, the mechanisms that drive cell survival during
DNAmismatchrepairsystemcouldrecognizeandrepairmistakesinprocessofDNAreplication,guardstabilityandintegralityofgenome. DNA错配修复系统可以识别并纠正DNA复制过程中出现的错误,保证基因组的稳定性和完整性。 kns50.chkd.cnki.net 6. Butthelargelooprepair,adistinctrepairfrommismatchrepair,isanunknownrepairsystem. ...
DNA-replication fidelitymismatch repairgenome instabilitymutator phenotypecancerIt has been suggested that an early event in the multistep progression of a normal cell to a tumor cell could be a defect that leads to an elevated mutation rate, thus providing a pool of mutants...Asad Umar...
The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progressi...