DNA Mismatch Repair (MMR) plays an important role in maintaining genomic fidelity and stability in all living organisms, ranging from bacteria to humans, and is known to be closely associated with DNA replication and present at DNA replication foci. MMR rapidly repairs mismatched base pairs ...
DNA mismatch repair (MMR) plays a critical role in ensuring the fidelity of DNA replication. Errors during DNA synthesis, if uncorrected, give rise to mutations in the next round of replication. MMR targets these errors resulting in excision of misincorporated bases in the newly synthesized DNA ...
DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in DNA replication fidelity, mutation avoidance and genome stability, all of which contribute significantly to the viability of cells and organisms. MMR is widely-used as a diagnostic biomarker for human cancers...
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous rec...
Top of pageMAMMALIAN MISMATCH REPAIR COMPLEXES BIOLOGICAL CONSEQUENCES OF MMR LOSS PROCESSING OF MODIFIED DNA BASES LITERATURE CITED The primary role of mismatch repair (MMR) is to maintain genomic stability by removing replication errors from DNA. This repair pathway was originally implicated in human...
DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases in daughter strands. However, whether the MutS–MutL complex coordinates MMR by ATP-dependent sliding on
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be eithe...
林奇综合征(Lynch syndrome, LS)曾被称为遗传性非息肉病性结直肠癌(HNPCC), 是一种显性遗传性癌症综合征, 由细胞错配修复(mismatch repair, MMR )基因的可遗传突变引起, 表现为易患结直肠癌、子宫内膜癌、卵巢癌、胃癌、小肠癌...
DNAmismatchrepairsystemcouldrecognizeandrepairmistakesinprocessofDNAreplication,guardstabilityandintegralityofgenome. DNA错配修复系统可以识别并纠正DNA复制过程中出现的错误,保证基因组的稳定性和完整性。 kns50.chkd.cnki.net 6. Butthelargelooprepair,adistinctrepairfrommismatchrepair,isanunknownrepairsystem. ...
Mismatch-repair (MMR) systems promote eukaryotic genome stability by removing errors introduced during DNA replication and by inhibiting recombination between nonidentical sequences (spellchecker and antirecombination activities, respectively). Following a common mismatch-recognition step effected by MutS-homologo...