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16.Singer B, Hang B. 1997. What Structural Features Determine Repair Enzyme Specificity and Mechanism in Chemically Modified DNA??. Chem. Res. Toxicol.. 10(7):713-732.17.Lindahl T. 1999. Quality Control by DNA Repair. 286(5446):1897-1905.18.Caldecott KW, Aoufouchi S, Johnson P, Shall...
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Mechanisms and functions of DNA mismatch repair - Li - 2008 () Citation Context ...ible for repairs of mismatches and small stranded DNA loops that are important in stabilizing the genome. The MMR mechanism is also believed to interact directly with NER and homologous recombination =-=[16, ...
activate the latent MutL endonuclease to nick the error-containing daughter strand. This nick provides an entry point for downstream repair proteins. Despite the well-established significance of strand-specific nicking in MMR, the mechanism(s) by which MutS and MutL assemble on mismatch DNA to allo...
Mechanism of DNA mismatch repair (MMR). There are five key MMR proteins in mammalian cells including MSH2, MSH3, MSH6, MLH1, and PMS2. These proteins form heterodimer complexes to recognize and correct erroneous insertion, deletion, and misincorporation of bases that arise during DNA replication...
What are DNA mismatch repair proteins? The mismatch repair mechanism or mismatch repair machinery is are a group of proteins that work as a system carrying out MMR. There are at least three recognized MMR proteins dubbed "Mut." They have been identified through experimentation with bacter...
This mechanism occurs independently of the known focal hypermutation (kataegis), and is associated with activity of the DNA mismatch-repair pathway, which can provide the single-stranded DNA substrate needed by A3, and contributes to a substantial proportion of A3 mutations genome wide. Because ...
Although the molecular mechanism of MMR in the eukaryotic cell is still not completely understood, increased used of single-molecule analyses in the future may yield new insight into these unsolved questions. Introduction DNA mismatch repair (MMR) is a highly-conserved DNA repair pathway that plays...
16.Singer B, Hang B. 1997. What Structural Features Determine Repair Enzyme Specificity and Mechanism in Chemically Modified DNA??. Chem. Res. Toxicol.. 10(7):713-732.https://doi.org/10.1021/tx970011e 17.Lindahl T. 1999. Quality Control by DNA Repair. 286(5446):1897-1905.https://doi...