Background & Aims: Colon cancers with defective DNA mismatch repair (MMR) have peculiar molecular, pathologic, and clinical features, including high-level microsatellite instability, conspicuous lymphocytic infiltration, preferential location in the proximal colon, and better prognosis. Our aim was to ...
2. DNA mismatch repair 3. Non-homologous end joining 4. Homologous recombination 5. Interstrand crosslink repair 6. DPC repair 7. Base excision repair 8. Nucleotide excision repair 9. Direct repair 10. Using the mutational landscape for treatment prediction 11. Emerging concepts and summary CRediT...
Interestingly, W2 was unable to repair substrates with a strand break located 3′ to the mismatch, which is attributable to a large observed decrease in PfMutLα content. These data imply that antimalarial drug resistance can result from defective MMR. 展开 关键词: Malaria Drug resistance DNA ...
Genetic defects in DNA repair and DNA damage response genes often lead to an increase in cancer incidence. The role of defects is also associated with the modulation of hormone signaling pathways. A number of studies have suggested a role for estrogen in the regulation of DNA repair activity. ...
摘要: A role for the Mut L homologue-1 (MLH1) protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpointarrest after 6-thioguanine (6-TG) exposure was suggested previously. Apotential role for MLH1 in G, arrest and/or G,-S transition after damage...
DNA mismatch repair: Molecular mechanism, cancer, and ageing DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important cellular functions. In its role in post-replication repair, MMR s... P Hsieh,K Yamane - 《Mechanisms of Ageing & Development》 被引量: 494发...
left. Exposures for tumors analyzed by WGS are displayed on the right. AC1 clock-like, spontaneous deamination; AC2 and AC13 altered APOBEC activity; AC3 defective HR; AC6 defective DNA mismatch repair; AC7 ultraviolet light exposure; AC10 altered POLE activity.dScatter plot of measures of ...
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8–MCM9 complex and compromises DNA mismatch repair in cancer cells ArticleOpen access09 July 2020 Main Accounting for 2% of all cancers in women, but ranking fifth among the causes of all cancer-related deaths in women, ovarian can...
Lynch syndrome is caused by pathogenic germline variants in the DNA mismatch repair (MMR) genes, predisposing individuals to malignancies, incl... Hazal Ser Merve,Baykal Duru,White Jessica D,... - Neuro-Oncology 被引量: 0发表: 2024年 Oncometabolites as Regulators of DNA Damage Response and ...
L Stojic,R Brun,J Jiricny - 《Dna Repair》 被引量: 659发表: 2004年 Repair of Double-Strand Breaks by Homologous Recombination in Mismatch Repair-Defective Mammalian Cells We have now examined homologous recombination in mismatch repair (MMR)-defective ES cells to investigate both the frequency ...