Mismatch repairImmune checkpoint blockadeTumor mutation burdenCancer immunotherapyMicrosatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. ...
DNA mismatch repairMsh2Mlh1Hereditary non-polyposis colon cancerLynch syndromeGermline mutations in DNA mismatch repair (MMR) genes are the cause of hereditary non-polyposis colorectal cancer/Lynch syndrome (HNPCC/LS) one of the most common cancer predisposition syndromes, and defects in MMR are also...
2020年11月,来自美国西南医学中心的傅阳心教授和李国民教授团队在国际顶尖肿瘤学期刊Cancer Cell上发表题为"DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity"的研究性论文。该团队通过分析TCGA...
2021年11月3日,香港大学李嘉诚医学院Jason Wong副教授领导的研究团队在Science Advances发表题为Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer的研究论文,首次发现了MMR可以独立于DNA复制外修复由5-甲基胞嘧啶(5-methylcytosine)脱氨基诱导的...
课程主讲: 所属机构: 所属分类:大学综合 下载方式:百度网盘【mp4】233.83MB 播放帮助:查看网盘播放说明 暂无预览 添加快捷方式到桌面 合集网盘下载DNA Mismatch Repair in Cancer视频教程 Guo-Min Li 2讲 美国肯塔基大学的相关介绍 第1讲 DNA Mismatch Repair in Cancer(一).mp4 第2讲 DNA Mismatch Repair in ...
14.Müller A, Fishel R. 2002. Mismatch Repair and the Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC). Cancer Investigation. 20(1):102-109. 15.Lindahl T. 1974. An N-Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues. ...
AmodioV, Lamba S, Chilà R, et al. Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance. Cancer Cell. 2023;41(1):196-209.e5. doi:10.1016/j.ccell.2022.12.003. 来源于:Of Studies ...
DNA mismatch repair: Molecular mechanism, cancer, and ageing DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important cellular functions. In its role in post-replication repair, MMR s... P Hsieh,K Yamane - 《Mechanisms of Ageing & Development》 被引量: 494发...
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Cancer Res. 66, 3323–3330 (2006). Article CAS PubMed PubMed Central Google Scholar Sharma, S. et al. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal ...
DNA mismatch repair (MMR) has been recently implicated to play a significant role in breast cancer progression, however, few studies have examined how various carcinogens affect MMR system in breast cancer cells. The present study employs an in vivo MMR assay developed in our laboratory to assess...