Consequently the DNA repair or DNA damage response function will be deficient or impaired, and damages will accumulate. Such DNA damages can cause errors during DNA replication or inaccurate repair, leading to mutations that can give rise to cancer. Increased oxidative DNA damages also cause ...
1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 封面图来源:pixabay 版权声明/免责声明 本文为授权转载文章。 本文仅作信息交流之目的,不提供任何商用、医用、投资用建议。 文中图片、视频、字...
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1. Future Oncol. 7, 253–261 (2011). Article CAS PubMed Google Scholar Uringa, E. J. et al. RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol. Biol. Cell 23, 2782–2792 (2012). Article ...
近日，美国洛克菲勒大学Agata Smogorzewska研究组在Nature上发表了文章Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer，通过对FA鳞状细胞癌患者的基因组和外显子组进行测序，发现FA修复途径的缺陷会导致基因组存在大量的结构变异，且FA途径的缺失会导致上皮-间质转变和增强角质细胞固有的...
Environmental and Molecular MutagenesisS.X. Li, A. Sjolund, L. Harris, J.B. Sweasy, DNA repair and personalized breast cancer therapy, Environ. Mol. Mutagen. 51 (2010) 897-908.Li SX, Sjolund A, Harris L, Sweasy JB. DNA repair and personalized breast cancer therapy. Environ Mol ...
2024年1月10日,意大利斯维泽拉大学生物医学研究所Silvia Monticelli与Petr Cejka教授共同在国际知名期刊《Nature》发表了题为:DNA sensing and repair team up against cancer的论文。细胞DNA通常存在于细胞核中,细胞核外的细胞质DNA十分少见。细胞质中的DNA能够作为一种异常信号调控细胞生命活动,例如发生病毒感染或癌症...
近日,美国洛克菲勒大学Agata Smogorzewska研究组在Nature上发表了文章Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer,通过对FA鳞状细胞癌患者的基因组和外显子组进行测序,发现FA修复途径的缺陷会导致基因组存在大量的结构变异,且FA途径...
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy. Sig Transduct Target Ther 6, 254 (2021). doi.org/10.1038/s41392-[2] Perkhofer L, Gout J, Roger E, Kude de Almeida F, Baptista Simões C, Wiesmüller L, Seufferlein T, ...
This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in mill...
P. (1995), DNA repair and inherited cancer. Journal of Gastroenterology and Hepatology, 10: 108–109. doi: 10.1111/j.1440-1746.1995.tb01059.x Author Information University of Melbourne Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia * H. C. Ee, University ...