同时揭示了cGAS蛋白作为抗病毒分子外具有的抗癌作用,以及其分子激活途径。 2024年1月10日,意大利斯维泽拉大学生物医学研究所Silvia Monticelli与Petr Cejka教授共同在国际知名期刊《Nature》发表了题为:DNA sensing and repair team up against cancer的论文。 细胞DNA通常存在于细胞核中,细胞核外的细胞质DNA十分少见。细...
Alot of research is being performed on the modulation of DNA repair and its exploitation as a therapeutic principle to enhance the effects of chemotherapy. This paper outlines chemotherapy-induced DNA damage, its repair, consequences and the current state of DNA repair inhibitor development.D.C. ...
1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 封面图来源:pixabay 版权声明/免责声明 本文为授权转载文章。 本文仅作信息交流之目的,不提供任何商用、医用、投资用建议。 文中图片、视频、字...
This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in mill...
Consequently the DNA repair or DNA damage response function will be deficient or impaired, and damages will accumulate. Such DNA damages can cause errors during DNA replication or inaccurate repair, leading to mutations that can give rise to cancer. Increased oxidative DNA damages also cause ...
1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 公众号内回复“肿瘤免疫”或扫描下方图片中的二维码免费下载《小药说药肿瘤免疫全集》的PDF格式电子书! 公众号已建立“小药说药专业交流群”微信行业交流群以及读者交流群,扫描下方小编...
近日，美国洛克菲勒大学Agata Smogorzewska研究组在Nature上发表了文章Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer，通过对FA鳞状细胞癌患者的基因组和外显子组进行测序，发现FA修复途径的缺陷会导致基因组存在大量的结构变异，且FA途径的缺失会导致上皮-间质转变和增强角质细胞固有的...
近日,美国洛克菲勒大学Agata Smogorzewska研究组在Nature上发表了文章Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer,通过对FA鳞状细胞癌患者的基因组和外显子组进行测序,发现FA修复途径的缺陷会导致基因组存在大量的结构变异,且FA途径...
Book description DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clini ... read full description Purchase book Share this bookBrowse...
DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Editionprovides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment....