近日,一篇发表在国际杂志Cancer Discovery上题为“GTP signaling links metabolism, DNA repair, and responses to genotoxic stress”的研究报告中,来自密歇根大学等机构的科学家们通过研究揭示了名为GTP的特殊核苷酸代谢产物如何以一种意想不到的方式来控制癌症对放疗和化疗的反应。 研究者Daniel Wahl博士说道,我们了解...
DNA repairDNA damageMETABOLISMMETABOLIC disordersENERGY metabolismThis document is an editorial from the International Journal of Molecular Sciences that discusses the intricate relationship between DNA damage response (DDR) and metabolism. It highlights the importance of maintaining genomic integrity and the ...
近日,该课题组在Cancer Discovery杂志上发表了题为GTP signaling links metabolism, DNA repair, and responses to genotoxic stress的研究论文,进一步揭示了GTP 信号传导通路与DNA损伤修复及对基因毒性应激反应的相关性。 在这项研究中,该...
Metabolism plays an important role in response to DNA damage, however the underlying mechanisms are less clear. Here, the authors identify a non-canonical role of IMPDH2 wherein it is recruited to the chromatin following DNA damage and mediates PARP1-dependent DNA damage repair via the regulation...
Siteman Cancer Center's DNA Metabolism and Repair Program includes 23 investigators Search Use of stem tissue in dental along with Posted onDecember 29, 2024 Reply The average extensive needs score for cancer clients addressed with immune checkpoint inhibitors was 39.2 ± 17.2. Customers reporte...
Genetic Susceptibility to Lung Cancer The Role of DNA Damage and Repair Purpose. The study was undertaken to determine the metabolism of dexrazoxane (ICRF-187) to its one-ring open hydrolysis products and its two-rings opened m... MR Spitz,Q Wei,Q Dong,... - 《Cancer Epidemiology Biomarker...
J. Jr. Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Semin. Cancer Biol. 20, 329–339 (2010). Article CAS PubMed PubMed Central Google Scholar Ellis, N. A. et al. The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83, 655–...
The use of metformin, salinomycin, DECA-14, rapamycin, and other drugs may help prevent the development of radioresistant cells by inhibiting CSC self-renewal or redox capacity [52, 66]. (7) Tumor metabolism. An increasing number of studies demonstrated that radioresistance is closely associated...
DNA-protein crosslinks), and interference with nucleotide metabolism and DNA synthesis. On the other hand, cancer cells activate various DNA repair pathways and repair DNA damages induced by cytotoxic drugs. The purpose of the current review is to present the major types of DNA damage induced by...
2. DNA damages are frequent, and DNA repair processes can be overwhelmed Tens of thousands of DNA damages occur per day per cell, on average, in humans, due to reactive molecules produced by metabolism or by hydrolytic reactions in the warm aqueous cellular media. Some types of such endogenou...