A low activity of DNA repair genes makes tumor cells more sensitive to therapy, but on the other hand, non-tumor cells getting lesions could form second primary cancer. Contrary, high activity of DNA repair genes counteracts attempted therapy. It means an individualized therapy based on ...
2024年12月3日，南京医科大学沈洪兵院士团队在期刊《eBioMedicine》上发表了题为“Systematic identification of pathogenic variants of non-small cell lung cancer in the promoters of DNA-damage repair genes”的研究论文。研究结果表明，除了蛋白质截断变异外，DDR基因的功能启动子变异也可能致病，并导致肺癌易感性。
Single nucleotide polymorphisms of RecQ1, RAD54L and ATM genes are associated with reduced survival of pancreatic cancer. J. Clin. Oncol. 24, 1720–1728 (2006). Article CAS PubMed Google Scholar Li, D. et al. Significant effect of homologous recombination DNA repair gene polymorphisms on ...
DNA Damage Response and DNA Repair in Cancer AI-generated audio 25:41The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer ...
Lung cancer (LC) is the leading cause of cancer-related death worldwide and tobacco smoking is the major associated risk factor. DNA repair is an important process, maintaining genome integrity and polymorphisms in DNA repair genes may contribute to susceptibility to LC. To explore the role of ...
突变或未知应突变使用PARP 抑制剂治疗，取决于单独 NHT治疗的早期进展的危险因素，并且需与患者进行共同决策 原文阅读：https://www.urotoday.com/conference-highlights/eau-2024/eau-2024-prostate-cancer/151067-eau-2024-parp-inhibitors-only-for-patients-with-alterations-in-dna-repair-genes-no.html ...
pA major goal of current cancer research is to understand the functional consequences of mutations in recombinational DNA repair genes. The introduction of artificial recombination substrates into living cells has evolved into a powerful tool to perform functional analysis of DNA double strand break (DS...
[1].Elizabeth R. Plimack , Roland L. Dunbrack, Timothy A. Brennan,et al., Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer. Euro Urol 68 (2015) 959–967 [2].Min Yuen Teo, Kenneth Seier, Irina Ostrovanya, et al...
Zhaoming Wang教授携团队对4402例儿童肿瘤幸存者的全基因组测序数据进行分析,研究成果2020年6月发表在 Journal of Clinical Oncology(IF= 32.956 ),深入探讨DNA修复基因(DNA repair genes,DRGs)的致病胚系遗传变异(Pathogenic Germline Mutations,PGMs)与肿瘤不同放化疗方案间的联合效应对继发肿瘤发生风险的影响,有助于鉴...
DNA repair pathways can enable tumor cells to survive DNA damage induced by chemotherapy and thus provide prognostic and/or predictive value. We evaluated Affymetrix gene expression profiles for 145 DNA repair genes in untreated breast cancer (BC) patients (n = 684) and BC patients treated with ...