Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described he...
Mutation Research 577 (2005) 275–283ReviewHuman DNA repair genes, 2005Richard D. Wooda,∗, Michael Mitchellb, Tomas LindahlcaUniversity of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue,Pittsburgh, PA 15213, USAbCancer Research UK, London Re...
DNA repair genes hMLH1 MGMT Epigenetics 1. Introduction: Gene inactivation by promoter hypermethylation in human cancer The cancer cell differs from a normal cell in its genotype [1]. Gross alterations such as the aneuploidy state, more discrete deletions (loss of heterozygosity) or gains (gene ...
Because of its biological function in nucleotide excision repair, functionally significant XPF gene polymorphisms are candidates for influencing cancer susceptibility and overall genetic stability. Nucleotide sequence diversity estimates for XPF are similar to the lipoprotein lipase and beta-globin genes. 展开...
Astrocytoma is the most common type of primary brain tumor and is known for its high degree of treatment resistance and rapid disease progression109,110. Research has revealed the impact of DNA repair genes, especially NEIL3, on glioblastoma progression and resistance. NEIL3 knockdown increased DNA...
Astrocytoma is the most common type of primary brain tumor and is known for its high degree of treatment resistance and rapid disease progression109,110. Research has revealed the impact of DNA repair genes, especially NEIL3, on glioblastoma progression and resistance. NEIL3 knockdown increased DNA...
Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand cross-links (ICLs), which block replication, transcription, and linear repair pathways by preventing DNA strand separation and trigger apoptosis. It...
However, overexpression of key FA genes failed to increase HDR beyond frequencies seen in control strains14. We reasoned that adding substrates for desired DNA repair pathways to template DNA would be an effective approach to activate desired DNA repair activities. Here, we report that adding ...
Analysis of these regions using ENCODE data shows that they are in general enriched in bound factors involved in DNA damage repair and have actively transcribed genes. However, both highly transcribed regions as well as transcriptionally inactive regions can form HIRs. The results also indicate that...
Activated c-KIT reverts REtr-induced DNA damage and apoptosis. In the presence of activated c-KIT, REtr-downregulated DNA-repair genes are re-expressed leading to an enhancement of DNA-repair efficiency via homologous recombination. Together, our results provide new mechanistic insight into REtr ...