Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described he...
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that...
Mutation Research 577 (2005) 275–283ReviewHuman DNA repair genes, 2005Richard D. Wooda,∗, Michael Mitchellb, Tomas LindahlcaUniversity of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue,Pittsburgh, PA 15213, USAbCancer Research UK, London Re...
Human DNA repair genes. Wood RD, ∗ ∗ University of Pittsburgh Cancer Institute, S867 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261. Mitchell M, Sgouros J, Lindahl T. Science 2001;291:1284–1289.doi:10.1016/s0002-9394(0...
polyps, focusing on mutation of BRAF and KRAS and alterations of TP53 and the DNA repair genes O-6-Methylguanine DNA Methyltransferase (MGMT) and MLH1... A Lugli,JR Jass - 《Verh Dtsch Ges Pathol》 被引量: 44发表: 2006年 Genetic and enzymic studies on the recombination process in Bacill...
Preferential DNA Damage and Poor Repair Determine ras Gene Mutational Hotspot in Human Cancer BACKGROUND: Mutations in ras genes are commonly found in human cancers and in animal models. Although mutations at codons 12, 13, and 61 of H-, N- and K-ra... Z Feng,W Hu,JX Chen,... - ...
Hereditary nonpolyposis colorectal cancer (HNPCC) is a common inherited form of neoplasia caused by germline mutations in DNA mismatch repair (MMR) genes. MMR proteins have been reported to associate with several proteins, including the human exonuclease
These include some of the genes involved in the regulation of DNA repair and nuclear structure, which cause the progeroid syndromes when mutated, as well... Warren,S.,Browner,... - 《American Journal of Medicine》 被引量: 376发表: 2004年 Hierarchical deterioration of body systems in Werner...
Human genetics is the study of the human genome and the transmission of genes from one generation to the next. The human genome consists of 23 pairs of chromosomes (22 pairs of homologous chromosom...
The major mechanism of repair of damage to DNA involves a conceptually simple process of enzymatic excision and resynthesis of small regions of DNA. In man and other mammals, this process is regulated by several gene loci; up to 15 mutually complementary genes or gene products may be involved....