These genes function in a diverse set of pathways that involve the recognition and removal of DNA lesions, tolerance to DNA damage, and protection from errors of incorporation made during DNA replication or DNA repair. Additional genes indirectly affect DNA repair, by regulating the cell cycle, ...
1. 去氧核醣核酸修复基因 名词解释资料库:... ... 2.肿瘤抑制基因( tumor suppressor genes) 3.去氧核醣核酸修复基因(DNA repair genes) 甲苯: toluene; ... b2322858.blogspot.com|基于15个网页 2. 去氧核醣核酸核酸修复 ... (body mass index, BMI) 、去氧核醣核酸核酸修复(DNA repair genes)及...
Mutations that attenuate homologous recombination (HR)-mediated repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as ‘BRCAness’1. BRCAness tumours arise from loss-of-function mutations in 22 genes1. Of these genes, all but ...
12:10:32 【官方双语】MIT分子生物学第一部分:DNA复制及修复【全109集】 BiologyOnline 【192集全】 • 看动画学英语(生物、物理、化学)少儿启蒙系列合集 北斗斗的长工 Kurzgesagt科普-【中英字幕】地球上最致命的生物——噬菌体 Artist_Kur科学 DNA损伤和修复( DNA Damage and Repair) ...
DNA sequencing of the transposon insertion sites identified three genes with regulatory functions (relA, rpoE2, and hpr) and a DNA repair gene (uvrC). Various phenotypes of the mutants were determined, including their behavior on several indicator media and in symbiosis. All of the mutants ...
^Buschta-Hedayat N, et al. Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6090-5. ^Sugasawa K, et al. A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev. 20...
Double Strand Break Repair proteins repair broken chromosomes. Using technologies and information from the Human Genome Project, we have previously determined that the DNA sequence of DNA repair genes varies within the human population. An average of 3-4 different variants were found that affect the...
FA genes play a role in DNA damage repair and genomic stability via the ubiquitination of the FANCD2/FANCI complex [30], [31], [32]. Although we have excluded patients clinically diagnosed with FA/DC, we found loss of function variants in FA/DC genes probably due to marked clinical and...
Differential introduction of DNA damage and repair in mammalian genes transcribed by RNA polymerases I and II Mol. Cell. Biol., 11 (1991), pp. 2245-2252 Google Scholar Waga et al., 1994 S. Waga, G.J. Hannon, D. Beach, B. Stillman ...
(DNA methylation and miRNA) occur in genes encodingDNA repair proteins, the repair process may be impaired, increase DNA damage and potentially contributing to different diseases, includingcervical carcinoma. This could impact the elimination of platinum-DNA adducts, whose persistence supports the...