Colon Cancer Genetics Group, Academic Coloproctology, Division of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK.spFamilial CancerClark AJ, Barnetson R, Farrington SM, Dunlop MG. Progno- sis in DNA mismatch repair deficient colorectal cancer: are all MSI tumours equivalent...
此外,DNA错配修复的缺陷也会增加遗传性结肠癌(hereditary colon cancer)的风险。 事实上,在许多类型的癌症中,一个或多个修复系统被完全或部分关闭。这使癌细胞的DNA变得不稳定,这是癌细胞经常突变并对化疗产生抗性的一个原因。同时,这些病态细胞对仍然在运行的修复系统更加依赖,如果没有这些修复系统,它们的DNA将变得...
Survival benefit with adjuvant chemotherapy in stage III microsatellite-high/deficient mismatch repair colon cancer: a systematic review and meta-analysis Article Open access 20 January 2022 Defective Mismatch Repair Status was not Associated with DFS and OS in Stage II Colon Cancer Treated with Adj...
DNA mismatch repairMsh2Mlh1Hereditary non-polyposis colon cancerLynch syndromeGermline mutations in DNA mismatch repair (MMR) genes are the cause of hereditary non-polyposis colorectal cancer/Lynch syndrome (HNPCC/LS) one of the most common cancer predisposition syndromes, and defects in MMR are also...
Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy. A Pooled Analysis From 2 Randomized Clinical Trials. Published Online: October 5, 2017. doi:10.1001/jamaoncol.2017.2899 ...
nascent strand, removal of the mismatched strand, and finally resynthesis and ligation to restore the double helix. Deficiencies inMMRgenes increasemutation ratesby several orders of magnitude and leads to a predisposition to cancer, most frequently colon cancer (Jiricny, 2013; Li and Martin, 2016...
研究者观察到,5种HR相关蛋白,乳腺癌1型易感蛋白(breast cancer type 1 susceptibility protein 1,BRCA1)、BRCA2、RAD51C、RAD51D和RAD51,在狨猴细胞中上调,但只有除RAD51之外的其余4种提高了人类胚胎干细胞中的HR效率[45]。这项研究表明,不同物种...
Deficient DNA mismatch repair: a common etiologic factor for colon cancer Hereditary non-polyposis colon cancer (HNPCC), the most common form of hereditary colon cancer, is a syndrome of deficient DNA mismatch repair (MMR). Five,... Peltomki Pivi - 《Human Molecular Genetics》 被引量: 1341发...
Mutations in the DNA mismatch repair gene MLH1 associated with early-onset colon cancer. J Pediatr 2006;148(6): 837-9.Marcos I, Borrego S, Urioste ... Marcos,I.,Borrego,... - 《Journal of Pediatrics》 被引量: 13发表: 2006年 Mutation in the DNA mismatch repair gene homologue hMLH 1...
In the HNPCC population (up to 70 years of age), the cancer risks are 80% in colon, 20–60% in endometrium, 11–19% in stomach, and 9–11% in ovary, while, in the general population, the risks are 5.5% in colon, 2.7% in endometrium, <1% in stomach, and 1.6% in ovary (...