The proficiency or deficiency of mismatch repair was determined by immunohistochemistry. Primary outcome was the risk for acute colon cancer surgery given as the Odds Ratio (OR) in the univariable and multivariable analyses. Acute colon cancer surgery was defined as surgery performed during the same ...
A well-defined subtype of colorectal cancer (CRC) is characterized by a deficiency in the mismatch repair (MMR) pathway. MMR deficiency not only contributes to the pathogenesis of a large proportion of CRC, but also determines the response to many of the drugs that are frequently used to ...
A. et al. Model-based prediction of defective DNA mismatch repair using clinicopathological variables in sporadic colon cancer patients. Cancer (in press). Barrow, E., McMahon, R., Evans, D. G., Levine, E. & Hill, J. Cost analysis of biomarker testing for mismatch repair deficiency in ...
(1999). "Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency." Oncogene 18(56): 8044-7. :Bader S, Walker M, Hendrich B, Bird A, Bird C, Hooper M, Wyllie A. Somatic frameshift mutations in the MBD4 gene of sporadic colon can- cers...
Colorectal cancer Lynch syndrome Mismatch repair deficiency Screening Access this article Log in via an institution Subscribe and save Springer+ Basic €32.70 /Month Get 10 units per month Download Article/Chapter or eBook 1 Unit = 1 Article or 1 Chapter Cancel anytime Subscribe now Buy Now...
The anti–programmed death receptor 1 inhibitor nivolumab previously showed activity in mismatch repair (MMR)–deficient colon cancer. We hypothesized that nivolumab would have activity in patients with MMR-deficient, noncolorectal tumors. PATIENTS AND METHODS Eligible patients with relapsed or refractory ...
Colorectal cancer (CRC) remains one of the most prevalent cancers worldwide. In sporadic CRC, mutations frequently occur in the DNA mismatch repair (MMR) pathway. In addition, germline MMR mutations have been linked to Lynch syndrome, the most common form of hereditary CRC. Although genetic muta...
Bader S, Walker M, Hendrich B, Bird A, Bird C, Hooper M, Wyllie A (1999) Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. Oncogene 18:8044–8047 ArticlePubMedCASGoogle Scholar
this condition may be termed as “constitutional mismatch repair-deficiency (CMMR-D) syndrome”. To give an overview of the current knowledge and its implications of this recessively inherited cancer syndrome we summarise here the genetic, clinical and pathological findings of the so far 78 reported...
Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells.Deficiency of DNA mismatch repair is a common... - 《Journal of the National Cancer Institute》 被引量: 0发表: 2000年 Genetic and sequence analysis of frameshift mutations induced by IC...