Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res. 62, 2447–2454 (2002). CAS PubMed Google Scholar Jung, B. H. et al. Activin type 2 receptor restoration in MSI-H colon cancer suppresses ...
Mismatch repair and colon cancer: mechanisms and therapies explored. Trends Mol. Med. 22, 274-289.Li SK, Martin A (2016) Mismatch repair and colon cancer: mecha- nisms and therapies explored. Trends Mol Med 22(4):274-289Li SK, Martin A. Mismatch Repair and Colon Cancer: Mechanisms and...
Mismatch repair status predicts survival after adjuvant treatment in stage II colon cancer patientsadjuvantcancerchemotherapycolondMMRStage II colon cancer is primarily a surgical disease. Only a still not well-defined subset of patients may benefit from postoperative adjuvant chemotherapy. The relationship...
Colorectal cancer (CRC) remains one of the most prevalent cancers worldwide. In sporadic CRC, mutations frequently occur in the DNA mismatch repair (MMR) pathway. In addition, germline MMR mutations have been linked to Lynch syndrome, the most common form of hereditary CRC. Although genetic muta...
Mismatch repair (MMR) testing is recommended in the Netherlands for all patients under 70 years of age with newly diagnosed colorectal cancer (CRC) in order to identify Lynch syndrome. T1 CRC can be removed by local excision or oncological surgical resection. We evaluated the frequency of MMR ...
Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer Article Open access 07 September 2020 Survival benefit with adjuvant chemotherapy in stage III microsatellite-high/deficient mismatch repair colon cancer: a systematic review and meta-ana...
5. Sargent DJ, Marsoni S, Monges G, et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer.J Clin Oncol. 2010;28(20):3219-3226. doi:10.1200/JCO.2009.27.1825 ...
Slightly lower risks for colon cancer and higher risks for endometrial cancer have been reported in families with MSH6 alterations. It should be noted that double-mutant MSH3−/− MSH6−/− mice have phenotypes very similar to those of MSH2−/− (de Wind et al., 1999, Edelmann et...
Mismatch Repair Proteins in Recurrent Prostate Cancer Though originally identified primarily in association with a predisposition to hereditary colon cancer, mismatch repair defects have been identified in man... J Jarzen,A Diamanduros,KD Scarpinato - 《Advances in Clinical Chemistry》 被引量: 12...
Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100 percent of early-stage colon cancers with mismatch repair deficiencies, according to results reported at