However, recent data suggest that TTFields may also attenuate DNA damage repair and replication fork dynamics, providing a potential platform for therapeutic combinations incorporating standard-of-care treatments and targeted DNA damage response inhibitors (DDRi).Methods We have used patient-derived, ...
因此,细胞进化出了一个复杂的生化途径系统来处理这种威胁,统称为DNA损伤应答(DNA-damage response,简称DDR),以防止有害的突变被继续传递。 “合成致死”的概念用于描述两个功能性基因同时失活导致细胞死亡的现象,随着PARP抑制剂的成功,“合成致死”领域引起大家广泛的关注。在伴有DDR某条通路缺陷的肿瘤细胞中,DNA修复...
DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications Article 12 November 2024 DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy Article Open access 09 July 2021 References Bo...
DNA damage response inhibitors, for example BRCA1/2 germline mutated cells are sensitive to poly (ADP-ribose)polymerase(PARP) inhibitors. The aims of this review are to discuss specific DNA damage response defects in breast cancer and to present the current stage of development of variousDDR...
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suffer from replic
olaparib was the first DDR-related drug under clinical trials, thus the total published papers increased. Clinical trials have increased since breast cancer had the first indications of PARP inhibitors approved by FDA in 2017. DDR, DNA damage response; SSB, DNA single-strand break; HRD, homogenou...
DNA damage and the subsequent various DNA damage response (DDR) pathways are important causative factors of vascular aging. Deficient DDR, which may result in the accumulation of unrepaired damaged DNA or mutations, can lead to vascular aging. On the other hand, over-activation of some DDR ...
molecule inhibitors (e.g. olaparib, talazoparib, niraparib, rucaparib, and velaparib) in BRCA-mutated ovarian cancer has provided proof-of-principle for exploiting synthetic lethality as a treatment strategy and has led to the development of other therapies targeting the DNA damage response. ...
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SA...
这表明,清除和降解失败的、潜在不稳定的修复中间产物(如CCF),可能是一种保护基因组完整性或抑制过度DNA损伤反应(DNA damage response, DDR)信号的机制。 表1 细胞质DNA的分子标记物 CCF 与疾病治疗 除了上述CCF和SASP的功能外,这些信号还可能对人类健康产生有害影响。在某些情况(如衰老)下,衰老细胞清除失败会导致...