DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implicationsThe DNA damage response (DDR) is a network of proteins that coordinate DNA repair and cell-cycle checkpoints to prevent damage being transmitted to daughter cells. DDR defects lead to ...
DNA damage response inhibitors, for example BRCA1/2 germline mutated cells are sensitive to poly (ADP-ribose)polymerase(PARP) inhibitors. The aims of this review are to discuss specific DNA damage response defects in breast cancer and to present the current stage of development of variousDDR...
因此,细胞进化出了一个复杂的生化途径系统来处理这种威胁,统称为DNA损伤应答(DNA-damage response,简称DDR),以防止有害的突变被继续传递。 “合成致死”的概念用于描述两个功能性基因同时失活导致细胞死亡的现象,随着PARP抑制剂的成功,“合成致死”领域引起大家广泛的关注。在伴有DDR某条通路缺陷的肿瘤细胞中,DNA修复...
Abbreviations: BLM: bloom syndrome protein; BRCA1: breast cancer protein 1; BRCA2: breast cancer protein 2; CtIP: CtBP-interacting protein; DDR: DNA damage response; DDRNAs: DNA damage response small RNAs; DDT: DNA damage tolerance; DNA-PKcs: DNA-dependent protein kinase catalytic subunit; ...
A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage response to remove faulty cells. Diana Romero-Zamora , Samuel Rogers & Anthony J. Cesare Article 02 January 2025 | Open Access Mms22-Rtt107 axis ...
olaparib was the first DDR-related drug under clinical trials, thus the total published papers increased. Clinical trials have increased since breast cancer had the first indications of PARP inhibitors approved by FDA in 2017. DDR, DNA damage response; SSB, DNA single-strand break; HRD, homogenou...
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SA...
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the se
9. Patrick G Pilié, et al. State-of-the-art strategies for targeting the DNA damage response in cancer. Nat Rev Clin Oncol. 2019 Feb;16(2):81-104. 10. G E Konecny, et al. PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions. Br...
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suffer from replic