www.dictall.com|基于4个网页 3. 损害反应 令人惊讶的是DNA损害反应(DNA damage response)会促使MSCs 分化为成熟黑色素细胞,而非造成细胞凋亡。成熟黑色素 … scimonth.blogspot.com|基于 1 个网页 更多释义 例句
ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway Here, the authors characterise the zinc finger protein ZNF827 as a single stranded DNA binding protein that accumulates at stalled replication forks to activate the ATR-CHK1 pathway and engage...
the answers to this intriguing question are yet to be fully elucidated. However, several proposed models may elucidate the definitive fate selectivity of the p53-induced response. One popular model suggests the dynamic behaviors of
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SA...
The Multifaceted Innate Response to Virus Infection AndrewLopez, ...Oliver I.Fregoso, inJournal of Molecular Biology, 2022 Overview of the DNA damage response (DDR) The first step in activation of the DDR is induction of DNA damage. DNA damage occurs through endogenous pathways, such asDNA rep...
The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
A growing body of evidence indicates that mTOR signaling is closely related to another cellular protection mechanism, the DNA damage response (DDR). Many factors important for the DDR are also involved in the mTOR pathway. In this review, we discuss how these two pathways communicate to ensure ...
Radioadaptive response is a biological defense mechanism in which low-dose ionizing irradiation elicits cellular resistance to the genotoxic effects of subsequent irradiation. However, its molecular mechanism remains largely unknown. We previously demonstrated that the dose recognition and adaptive response co...
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suffer from replic
The article reports on a study showing that diphosphorylated H2AX (diŸH2AX) exists in vivo in the early stages of DNA damage repair, which references the article "Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1," by N. ...