A key protein network alters their structure exposing telomere ends to signal mitotic stress, ultimately triggering a controlled DNA damage response to remove faulty cells. Diana Romero-Zamora , Samuel Rogers & Anthony J. Cesare Article 02 January 2025 | Open Access Mms22-Rtt107 axis ...
DNA repairis, in fact, only one class of a broader set of cellular responses referred to as theDNA damage response.DNA damage responsesinclude the activation ofcell cycle checkpoints, the activation ofapoptosis, and the activation of DNA damage tolerance. This latter mechanism allows a cell to...
www.dictall.com|基于4个网页 3. 损害反应 令人惊讶的是DNA损害反应(DNA damage response)会促使MSCs 分化为成熟黑色素细胞,而非造成细胞凋亡。成熟黑色素 … scimonth.blogspot.com|基于 1 个网页 更多释义 例句
The article reports on a study showing that diphosphorylated H2AX (diŸH2AX) exists in vivo in the early stages of DNA damage repair, which references the article "Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1," by N. ...
DNA damage response(DDR) encompasses a number of pathways and molecules that enable the cell to restore genomic alterations.184Becausegenomic instabilityis one of the emerging hallmarks of cancer, DDR dysfunction plays a pivotal role in cancer development.185Chou and Alawi186have shown that DNA damag...
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SA...
Abstract The maintenance of genome stability is essential for the cell as the integrity of genomic information guaranties reproduction of a whole organism. DNA damage occurring in response to different natural and nonnatural stimuli (errors in DNA replication, UV radiation, chemical agents, etc.) is...
DNA repair in response to anthracycline–DNA adducts: A role for both homologous recombination and nucleotide excision repair Doxorubicin, a widely used anthracycline anticancer agent, acts as a topoisomerase II poison but can also form formaldehyde-mediated DNA adducts. This has ... DMS Spencer,RA...
Double-strand break (DSB) repair at telomeres — the ends of linear chromosomes — can cause chromosome end fusions and genomic instability, which drives tumorigenesis. As several mechanisms protect mammalian telomeres from the DNA damage response, telom
Fig. 1: General overview of DNA damage response networks activate by DNA damage. Once cellular DNA damage occurs, the DDR is activated to protect damaged DNA integrity. The cell cycle is paused to provide cells an opportunity to activate DNA repair mechanisms. When the DNA damage is severe, ...