Review:DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosisTissue homeostasis requires a carefully-orchestrated balance between cell proliferation, cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly regulated by ...
In this review, colorectal cancer and its molecular pathology as well as DNA damage response is briefly introduced. Finally, the involvement of key components of this network in the initiation/progression, prognosis, response to treatment and development of drug resistance is comprehensively discussed....
[34]Mullenders L. Solar UV damage to cellular DNA: from mechanisms to biological effects[J]. Photochem Photobiol Sci, 2018, 17(12): 1842-1852. DOI: 10.1039/c8pp00182k. [35]Yan S, Sorrell M, Berman Z. Functional interplay betwe...
2A complex DNA damage response (DDR) network has been evolved to maintain the integrity and fidelity of genomic DNA. These DDR networks include DNA repair pathways themselves and a repertoire of regulatory signaling events which are closely related to other cellular processes such as cell cycle...
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SA...
Here, we review data obtained over the past decade and discuss the mechanisms that protect mammalian chromosome ends from the DNA damage response. We also discuss how telomere research has helped to uncover key steps in DSB repair. Last, we summarize how dysfunctional telomeres and the ensuing ...
Review article Molecular targets that sensitize cancer to radiation killing: From the bench to the bedside Biomedicine & PharmacotherapyJournal2023,Biomedicine & Pharmacotherapy SushmithaSriramulu, ...ShyamNyati 1.1DNA damage response mechanism TheDNA damage response(DDR) is an evolutionarily-conserved defens...
In addition to checkpoint activation, the DNA damage response leads to induction of transcriptional programs, enhancement of DNA repair pathways, and when the level of damage is severe, to initiation of apoptosis.6 All of these processes are carefully coordinated so that the genetic material is ...
The DNA damage response (DDR) is activated when DNA is altered by intrinsic or extrinsic agents. This pathway is a complex signaling network and plays important roles in genome stability, tumor transformation, and cell cycle regulation. Human papillomaviruses (HPVs) are the main etiological agents...
A growing body of evidence indicates that mTOR signaling is closely related to another cellular protection mechanism, the DNA damage response (DDR). Many factors important for the DDR are also involved in the mTOR pathway. In this review, we discuss how these two pathways communicate to ensure ...