Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy. Although DNA-damaging therapies advance the battle with cancer, resista
REVIEWMetastasisDamageDNA damage response genes play vital roles in the maintenance of a healthy genome. Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant downregulation, are associated with a wide spectrum of human disease, including a predisposition to the ...
DNA damage response inhibitors, for example BRCA1/2 germline mutated cells are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. The aims of this review are to discuss specific DNA damage response defects in breast cancer and to present the current stage of development of various DDR...
DNA damage activates a signaling cascade named DNA damage response (DDR) [5], in which cells respond to DNA damage by pausing cell cycle progression and trying to repair [7,203] (Fig.1). This complicated network of signaling channels made up of sensors, transducers, and effectors. The sens...
本文“Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention”在期刊Journal of Clinical and Translational Hepatology上发表。 投稿:2024年3月...
缩写:DDR: DNA damage responseSSB: Single-strand breaks DSB: Double-strand breaks HR: Homologous recombination NHEJ: Non-homologous end joining BER: Base excision repair NER: Nucleotide excision repair MMR: Mismatch repair PARP: Poly (ADP-ribose) polymerase ...
human body has evolved several systems to detect DNA damage and mediate its repair. Stephen Jackson and Jiri Bartek review recent work on how DNA lesions are dealt with at the molecular level, and show how an understanding of DNA-damage responses is providing new avenues for disease management....
The DNA damage responseDr. Vincenzo Costanzo – Cancer Research UK, UK Published on April 30, 2009 34 min Review Share Add to A selection of talks on Genetics & Epigenetics Genetic counseling: preconception, prenatal, perinatal Genetic counseling: preconception, prenatal, perinatal 42 min Prof....
In addition to checkpoint activation, the DNA damage response leads to induction of transcriptional programs, enhancement of DNA repair pathways, and when the level of damage is severe, to initiation of apoptosis.6 All of these processes are carefully coordinated so that the genetic material is ...
In this Review, we discuss the effects of different types of DNA damage on Pol II, important concepts of transcription stress, the manner in which TBLs are removed by TC-NER and how different tissues respond to TBLs. We also discuss the role of TBLs in ageing and the complex genotype鈥損...