In addition, a variety of inheritied syndromes with DNA repair defects convey a high risk of myelodysplasia and leukemia. Together, these pieces of evidence suggest that a fundamental defect in the DNA damage recognition and response pathways is an important component of leukemogenesis. Here, the ...
et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447, 725–729 (2007) Article ADS CAS PubMed Google Scholar Collis, S. J. & Boulton, S. J. Emerging links between the biological clock and the DNA damage response. Chromosoma 116, ...
One such case is DNA repair at the natural ends of linear chromosomes, known as telomeres, which can lead to chromosome-end fusions. Here, we review data obtained over the past decade and discuss the mechanisms that protect mammalian chromosome ends from the DNA damage response. We also ...
To avoid the disruption of telomere function, a host of telomere-binding and associated proteins are critically involved in maintaining structure and preventing subsequent activation of a DNA damage response. In addition to these factors, a multitude of DNA damage response proteins also normally ...
of DNA-damage responses is providing opportunities for improving disease detection and management. An integrated signalling and genome-maintenance network To combat threats posed by DNA damage, cells have evolved mechanisms—collectively termed the DNA-damage response (DDR)—to detect DNA lesions, signal...
The DNA damage response Dr. Vincenzo Costanzo –Cancer Research UK, UK Published on April 30, 200934 min Review Share Add to A selection of talks onCell Biology Gene structure, expression and regulation: DNA structure an…Gene structure, expression and regulation: DNA structure and replication...
The MRN interactor and endonuclease CtIP (CTBP-interacting protein) perform the short-range DNA end resection steps and undergo SUMOylation in response to DNA damage (Figure 4, subsection 2) [28,29,49,50,52,56–58]. SUMOylation of CtIP supports its recruitment to DSBs, DNA-resection and...
DNA damage responseRNA processingalternative splicingncRNAsp53Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, ...
dnaionizingdamagerepairradiationmismatch TumourReview DNAmismatchrepairandtheDNAdamageresponsetoionizing radiation:Makingsenseofapparentlyconflictingdata LynnM.Martin a, * ,BrianMarples b ,MaryCoffey a ,MarkLawler c ,ThomasH.Lynch d , DonalHollywood a ,LaureMarignol a a ProstateMolecularOncologyResearch...
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756–760 (2006). Article ADS CAS PubMed Google Scholar Mantoni, T. S., Lunardi, S., Al-Assar, O., Masamune, A. & Brunner, T. B. Pancreatic stellate cells radioprotect ...