cells might contribute to constitutive elevated expression of CD47 and promote immune evasion.#The CD47 "don't eat me" marker is upregulated following exposure to DNA damaging agents, including irradiation, a process that is dependent on Mre11, a key player in the DNA damage response pathway.do...
1 1Department of Molecular Genetics and Microbiology, Center for Virology, Duke University Medical Center, 213 Research Dr., CARL 424, DUMC 3054, Durham, NC 27710, USA The DNA damage response (DDR) has emerged as a critical tumour suppressor pathway responding to cellular DNA replicative stress...
Dun1 itself is activated for autophosphorylation in response to DNA damage. This finding established that DNA damage is indeed transduced by signal transduction, through a protein kinase, and was the first demonstration of what is now called the DNA damage response (DDR) pathway. The concept of ...
Specificity Protein-protein interactions DNA damage response Checkpoints 1. Introduction The DNA Damage Response (DDR) is an extraordinary, transient reconfiguring of cellular behaviour, driven by a massive cascade of post-translational events (primarily phosphorylation) downstream of DNA damage detection. ...
Open access Correspondence The DNA damage repair (DDR) pathway in biliary tract cancer (BTC): a new Pandora's box? Angela Dalia Ricci, Alessandro Rizzo , Giovanni Brandi To cite: Ricci AD, Rizzo A, Brandi G. The DNA damage repair (DDR) pa...
By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinog
Abstract Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. The protection of genome integrity is ensured by the so-called “DNA damage response” (DDR), a set of evolutionary-conserved events that, triggered...
cells evolved a complex and interplaying system, the so-called DNA damage response (DDR) [8,9]. During DDR, DNA lesions are detected, leading to the activation of a signal cascade resulting either in the repair or the tolerance of the DNA damage, thereby regulating the cellular outcome afte...
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as a component of the ATR-CHK1 kinase...
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy. Although DNA-damaging therapies advance the battle with cancer, resista