Alterations in the DNA damage response (DDR) pathways are emerging as novel targets for treatment across different cancer types. However, even though preclinical studies have shown the potential exploitation of DDR alterations in CRC, systematic and comprehensive testing is lagging behind and clinical ...
1 1Department of Molecular Genetics and Microbiology, Center for Virology, Duke University Medical Center, 213 Research Dr., CARL 424, DUMC 3054, Durham, NC 27710, USA The DNA damage response (DDR) has emerged as a critical tumour suppressor pathway responding to cellular DNA replicative stress...
Dun1 itself is activated for autophosphorylation in response to DNA damage. This finding established that DNA damage is indeed transduced by signal transduction, through a protein kinase, and was the first demonstration of what is now called the DNA damage response (DDR) pathway. The concept of ...
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy. Although DNA-damaging therapies advance the battle with cancer, resista
Open access Correspondence The DNA damage repair (DDR) pathway in biliary tract cancer (BTC): a new Pandora's box? Angela Dalia Ricci, Alessandro Rizzo , Giovanni Brandi To cite: Ricci AD, Rizzo A, Brandi G. The DNA damage repair (DDR) pa...
By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an intrinsic barrier against carcinog
Abstract Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. The protection of genome integrity is ensured by the so-called “DNA damage response” (DDR), a set of evolutionary-conserved events that, triggered...
As hippocampal neurons respond to diverse types of information1, a subset assembles into microcircuits representing a memory2. Those neurons typically undergo energy-intensive molecular adaptations, occasionally resulting in transient DNA damage3–5. Her
(Supplementary Fig.3f). The βTrCP-mediated MDM2 degradation pathway increases p53 activity during the DNA damage response (DDR)23. We observed that the expression ofβTrCPwas notably stimulated by exposure to therapeutic ionizing radiation and was further blocked by deletion ofMen1in MEF cells (...
The ensuing DNA damage response (DDR) leads to activation of Nox enzymes that produce ROS. ROS can then exert multiple effects either intrinsic to the cell that produces them or extrinsic (inflammation, cell defense, cell death, DNA damage etc). Diphenyleneiodonium (DPI) is an inhibitor of ...