DNA repairHemopoietic stem cellLeukemogenesisATM kinaseATR kinaseIn mammalian cells, the DNA damage response (DDR) prevents the replication and propagation of DNA errors to the next generation, thus maintaining genomic stability. At the heart of the DDR are the related signaling kinases ATM, ATR, ...
The DNA damage response (DDR) cascade and ROS (reactive oxygen species) signaling are both involved in the induction of cell death after DNA damage, but a mechanistic link between these two pathways has not been clearly elucidated. This study demonstrates that ROS induction after treatment of cel...
The ensuing DNA damage response (DDR) leads to activation of Nox enzymes that produce ROS. ROS can then exert multiple effects either intrinsic to the cell that produces them or extrinsic (inflammation, cell defense, cell death, DNA damage etc). Diphenyleneiodonium (DPI) is an inhibitor of ...
In general, DDR molecules can be subdivided into (a) DDR sensors, (b) DDR signal transducers, and (c) DDR effectors. For instance, the canonical molecular response to DNA double-strand breaks (DSBs) is highlighted by the recruitment of the MRN (MRE11-RAD50-NBS1) complex to a damage si...
inhibitors (PARPi) represent an effective therapeutic strategy for cancer patients harboring germline and somatic aberrations in DNA damage repair (DDR) genes... Angela Dalia Ricci,A Rizzo,C Bonucci,... 被引量: 0发表: 2020年 Understanding Patient Experience in Biliary Tract Cancer: A Qualitative...
cells evolved a complex and interplaying system, the so-called DNA damage response (DDR) [8,9]. During DDR, DNA lesions are detected, leading to the activation of a signal cascade resulting either in the repair or the tolerance of the DNA damage, thereby regulating the cellular outcome afte...
and DNA damage response (DDR), have been intensively studied in the brain development. Given its function in controlling cell proliferation, cell cycle progression, and cell death, a proficient DDR is vital in brain development and also in age-related neuropathy, including neurodegeneration. An aber...
response by radiotherapy primarily include: induction of immunogenic cell death to promote the proliferation and activation of T lymphocytes; activation of the cyclic GMP-AMP synthase-stimulator of interferon genes pathway to induce type Ⅰ interferon response; changing the phenotype of tumor cells to ...
(Supplementary Fig.3f). The βTrCP-mediated MDM2 degradation pathway increases p53 activity during the DNA damage response (DDR)23. We observed that the expression ofβTrCPwas notably stimulated by exposure to therapeutic ionizing radiation and was further blocked by deletion ofMen1in MEF cells (...
opens up a new dimension in the field of DNA repair; we discuss its impact on our current understanding of DNA repair processes and consider how it might influence cancer progression. Background Genomic stability is ensured by the DNA-damage response (DDR), a network of pathways that functions...