编码DDR的基因在癌症中经常发生突变,导致基因组不稳定,是许多癌症的内在特征,也是其生长、转移和对DNA损伤治疗 (如放疗) 反应能力的基础。2022年Florian在《nature reviews cancer》上发表了题为《Targeting DNA damage response pathways in cancer》的综述,描述了主要的DNA损伤检查点和修复途径,讨论了使用目前正在临床...
2、提出PARP抑制剂对HR缺陷肿瘤的成功基础,及其他合成致死相互作用在临床应用中的优越性和局限性。 近日由英国牛津大学肿瘤系的Groelly, F.J.教授在《nature reviews cancer》杂志上发表了名为“Targeting DNA damage response pathways in cancer”的回顾文章。在这篇综述中,作者描述了主要的DNA损伤检查点和修复途径...
inDNAdamageresponsepathwaysthatservetomain- getgenesp21andMdm2[3]andtestedwhetherthe taingenomicstability[1,2].CellslackingmouseHus1 increasedexpressionofthesegenesreflectedp53acti- arehypersensitivetocertaingenotoxins[3],andwe vationintheabsenceofHus1.Hus1 / p53 / and haveexploredthemolecularbasisforthis...
To maintain genome integrity, cells have evolved highly conserved defense mechanisms, collectively known as the DNA damage response (DDR), to identify the lesions, signal their presence, and activate the appropriate DNA repair pathway. In this chapter, we will discuss the recent advances in DDR, ...
Targeting DNA damage response pathways in cancer (Nat Rev Cancer;IF:69.8) Groelly FJ, Fawkes M, Dagg RA, Blackford AN, Tarsounas M. Targeting DNA damage response pathways in cancer. Nat Rev Cancer 2022. Correspondence to :andrew.blackford@imm.ox.ac.uk;madalena.tarsounas@oncology.ox.ac.uk...
The DNA damage response is a network of cellular pathways that sense, signal and repair DNA lesions. Surveillance proteins that monitor DNA integrity can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage, to prevent the generation of potentially deleterious mutations....
原名:Targeting DNA damage response pathways in cancer 译名:癌症中的DNA损伤反应通路 期刊:Nature Reviews Cancer IF:69.8 发表时间:2022年12月 通讯作者:Andrew N. Blackford和Madalena Tarsounas 通讯作者单位:牛津大学 DOI号:10.1038/s41568-022-00535-5 ...
3.M. Goldberg et al., MDC1 is required for the intra-S-phase DNA damage checkpoint.Nature421, 952-956 (2003). 4.Z. Lou, K. Minter-Dykhouse, X. Wu, J. Chen, MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.Nature421, 957-961 (2003). ...
Many viruses, with distinct replication strategies, activate DNA-damage response pathways, including the lentivirus human immunodeficiency virus (HIV) and the DNA viruses EpsteinBarr virus (EBV), herpes simplex virus 1, adenovirus and SV40. DNA-damage response pathways involving DNA-dependent protein ki...
It is likely that the DNA damage response pathways sense common intermediates, rather than the original damage. Indeed, the current view for eukaryotic cells is that all types of DNA damage are eventually converted to either single-strand (ssDNA) and double-strand DNA breaks (DSBs). Two ...