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The DNA damage response is essential to safeguard genome integrity. Although the contribution of chromatin in DNA repair has been investigated1,2, the contribution of chromosome folding to these processes remains unclear3. Here we report that, after the
DNA Damage Response DNA Repair Homologous Recombination Radiation Biology RNA-binding Proteins ATM Fused in Sarcoma PARP Introduction Exposure to genotoxic agents including ionizing radiation (IR),2 H2O2, and radiomimetic drugs poses a significant challenge to genomic integrity that is combated by evoluti...
Understanding the mechanism of age susceptibility to SARS-CoV-2 infection is important for targeted therapeutic approaches, which might in principle include the use of tASO-mediated inhibition of the telomeric DNA damage response. ACE2 also has a role in the regulation of blood pressure and the ...
but the biogenesis of these damage-related RNAs and their mechanisms of action remain unknown. We will explore how these new findings challenge the idea of proteins being the sole participants in the response to DNA damage and reveal a new and exciting aspect of both DNA repair and RNA biology...
The RNA Splicing Response to DNA Damage. Biomolecules 5, https://doi.org/10.3390/biom5042935 (2015). Article CAS PubMed PubMed Central Google Scholar Nguyen, E. D., Balas, M. M., Griffin, A. M., Roberts, J. T. & Johnson, A. M. Global Profiling of hnRNP A2/B1-RNA Binding ...
First, the genetic infor- mation stored in DNA has to be copied, or transcribed, into RNA in the cell nucleus and then the information contained in RNA must be interpreted in the cytoplasm to build proteins through a process known as transla- tion. Rather than being a simple process, the...
et al. The RNA Response to DNA Damage. J. Mol. Biol. 428, 2636–2651 (2016). Article CAS PubMed Google Scholar Gregersen, L. H. & Svejstrup, J. Q. The Cellular Response to Transcription-Blocking DNA Damage. Trends Biochem Sci. 43, 327–341 (2018). Article CAS PubMed PubMed ...
Non-coding RNA (ncRNA) molecules have been shown to play a variety of cellular roles; however, the contributions of different types of RNA to specific phenomena are often hard to dissect. To study the role of RNA in the assembly of DNA damage response (DDR) foci, we developed the RNase ...