[35]Yan S, Sorrell M, Berman Z. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress[J]. Cell Mol Life Sci, 2014, 71(20): 3951-3967. DOI: 10.1007/s00018-014-1666-4. [3...
2022年7月13日,罗切斯特大学Vera Gorbunova教授和浙江大学医学院赵阳研究员及其同事受邀在Nature Reviews Immunology上发表了题为“DNA damage and repair in age-related inflammation”的综述文章。作者首先介绍了DNA损伤造成炎症的机制,即通过细胞质核酸感受激活先天免疫通路。随后总结了炎症反应在几中重要的衰老相关事件中...
DNA Damage, Repair, and Cancer Metabolism. Front Oncol. 2018 Feb 5;8:15. Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional ...
The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
Dna RepairMirza-Aghazadeh-Attari, M.; Darband, S.G.; Kaviani, M.; Mihanfar, A.; Aghazadeh Attari, J.; Yousefi, B.; Majidinia, M. DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications. DNA Repair (Amst) 2018, 69, 34-52. [CrossRef]...
DNA damage response: three levels of DNA repair regulation. Cold Spring Harb. Perspect. Biol. 5, a012724 (2013). Article Google Scholar Boder, E. & Sedgwick, R. P. Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary ...
Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, ...
Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, ...
3.1 内源性DNA损伤3.2 外源性DNA损伤 4. DNA损伤与DNA变异 5. DNA损伤应答（DDR）途径 5.1 DNA修复机制5.2 细胞周期停滞与细胞凋亡 6. DNA损伤与疾病 7. 与DNA损伤修复相关的重组蛋白 1. 什么是DNA损伤？DNA损伤是指任何偏离其原始双螺旋结构的改变。所有细胞生物都会发生DNA损伤。2. 什么导致DNA损伤？...
胡晋川在诺贝尔化学奖得主 Aziz Sancar 教授实验室做博士后期间,主导开发了 Damage-seq 和 XR (eXcision Repair) -seq 方法,分别是目前唯一能以单碱基分辨率检测人类基因组上各种 DNA 加合物损伤位置和核苷酸切除修复发生位置的高通量测序方法。 点击可看大图...