Accumulation of DNA damage and the incapability of the cellular DNA repair machinery to fix DNA lesions seem to be contributors to aging and to age-associated diseases such as cancer. However, appropriated nutrition can protect against oxidative DNA damage and enhance DNA repair; therefore, dietary...
参考文献 [1] Hu J , Adar S . The Cartography of UV‐induced DNA Damage Formation and DNA Repair[J]. Photochemistry and Photobiology, 2017. [2] Chatterjee N , Walker G C . Mechanisms of DNA damage, repair, and mutagenesis[J]. Environmental and Molecular Mutagenesis, 2017, 58(1):235-2...
参考文献：[1] Sancar A., Lindsey-Boltz L.A., et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints [J]. Annu. Rev. Biochem. 2004; 73: 39-85.[2] Lindahl T. Instability and decay of the primary structure of DNA [J]. Nature. 1993; 362: 709-715.[3]...
[5] Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice and cancer [J]. DNA Repair. 2014;19:169–175. [6] Zhou BB, Elledge SJ 2000. The DNA damage response: Putting checkpoints in perspective [J]. Nature 408: 433–439. [7] Matsuoka S, Huang M, Elledge...
近日,来自英国爱丁堡大学遗传与癌症中心的Martin S. Taylor研究团队、剑桥大学癌症中心的Sarah J. Aitken和Duncan T. Odom研究团队合作在Nature杂志上发表题为Strand-resolved mutagenicity of DNA damage and repair的研究论文,该研究揭示了链不对称机制如何影响DNA损...
Chapter5 DNAdamage,repairandmutation 第一节DNA损伤 一、自发性损伤（spontaneousmutations）1、DNA复制错误校正后的错配率仍约在10-10左右2、互变异构(烯醇式-酮式结构互变)3、自发性的化学变化脱嘌呤和脱嘧啶脱氨（基）(deamination)作用 （1）脱嘌呤和脱嘧啶 •糖苷键断裂,嘌呤和嘧啶从DNA链的核糖磷酸骨架...
10.5DNA损伤与修复 DNA Damage and Repair 这门课程主要包括四个方面的内容:1、生物大分子的结构与功能:包括蛋白质、核酸、酶、聚糖等的分子组成,分子结构,结构与功能的关系及主要理化性质。2、物质代谢及其调节:包括糖、脂质、氨基酸、核苷酸、非营养物质代谢及物质代
[5] Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice and cancer [J]. DNA Repair. 2014;19:169–175. [6] Zhou BB, Elledge SJ 2000. The DNA damage response: Putting checkpoints in perspective [J]. Nature 408: 433–439. ...
5.Jackson AL, Loeb LA. 2001. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 477(1-2):7-21.6.De Bont R. 2004. Endogenous DNA damage in humans: a review of quantitative data. ...
2023年9月21日,深圳大学朱卫国团队在Nature Structural & Molecular Biology在线发表题为“PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair”的研究论文,该研究报道了丙酮酸脱氢酶1α (PDHE1α)催化丙...