DNA repairProteins that act on DNA, or are in close proximity to it, can become inadvertently crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs). DPCs are generated by different chemotherapeutics, environmental or endogenous sources of crosslinking agents, or...
Many diseases are caused by an accumulation of unresolved DNA damage. Learn how DNA damage is recognized, which marker proteins initiate DNA damage response and what repair mechanisms exist
Chronic stress affects the body’s endocrine and immune responses, potentially leading to immunosuppression. This weakened immune state can impair the skin’s ability to repair DNA damage caused by UV exposure and fight off cancerous cells. Furthermore, stress-related hormones like cortisol can influ...
which delivers them to cells all over the body. 它们被注入血管,好让它们传递至全身的细胞。 Once inside, when the cell exposes its DNA in order to copy it, 一旦抵达,当细胞为了复制 而暴露 DNA 时, they damage the building blocks of DNA’s double helix structure, 它们会损害 DNA 双股螺旋状...
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Sancar discovered the mechanisms used by cells to fix damage by ultraviolet radiation. Modrich laid bare a complex DNA-mending process called mismatch repair. “The basic research carried out by the 2015 Nobel laureates in chemistry has not only deepened our knowledge of how we function, but coul...
which can cause DNA damage over time. Extensive evidence has shown that endurance exercise (done most days of the week) like running, walking, swimming and biking extends neuromuscular, heart and cognitive health. At the same time, resistance ...
important when considering thedetrimental effects that UV light can have on your DNA-based experiments. In cells, DNA repair mechanisms can fix UV-damaged bases, but in purified plasmids, no such mechanisms exist, and unrepaired UV damage can be detrimental to the success of downstream ...