Investigation into the nature of DNA damage and repair have provided valuable insight into aging, human genetics and cancer. Now, there is deep interest in identifying free radical scavengers or antioxidants that inhibit oxidative DNA damage. This review describes all the possible mechanisms of DNA ...
Genomic instability is an important driver of ageing. The accumulation of DNA damage is believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction. However, emerging evidence shows that inflammation is another major conseq
Once cellular DNA damage occurs, the DDR is activated to protect damaged DNA integrity. The cell cycle is paused to provide cells an opportunity to activate DNA repair mechanisms. When the DNA damage is severe, cell death programs are activated. Dashed arrows indicate altered mechanisms. Alteration...
9、 Chen, S. H. and X. Yu (2019). "Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation." Nucleic Acids Res 47(3): 1321-1334.10、 De Vos, M., et al. (2012). "The diverse roles and clinical relevance of PARPs in DNA damage re...
DNA损伤修复功能异常是肿瘤发生发展的重要特点之一,突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能必需的蛋白质。如果有丝分裂之前这些基因组突变尚...
gammaH2AX: a sensitive molecular marker of DNA damage and repair. Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming gammaH2AX, is an early cellular response to the induction of DNA double-strand breaks. Detection of this phosphorylation event has emerged as a highly spe...
DNAdamage,repair,andrecombination F1MutagenesisF2DNAdamageF3DNArepairF4Recombination F1Mutagenesis 1.Mutation MutationareheritablepermanentchangesinthebasesequenceofDNA.1.1Pointmutation:isthesimplestmutation-asinglebasechange.Transition:purineorpyrimidineisreplacedbytheother AGTC F1Mutagenesis 1Mutation Transversion:a...
关键词:肿瘤;DNA 损伤修复;放疗;放射敏感性;机制 中图分类号:Q691 文献标识码:R 文章编号:1004-714X(2020)04-0442-04 DNA damage repair and radiosensitivity of tumor YANG Siqi1,YAO Yi1,2,SONG Qibin1,2,ZHENG Sihao2,GAO Yanjun1,2,WU Bin1 1. Cancer Center, Wuhan University ...
[5] Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice and cancer [J]. DNA Repair. 2014;19:169–175. [6] Zhou BB, Elledge SJ 2000. The DNA damage response: Putting checkpoints in perspective [J]. Nature 408: 433–439. ...
Mass spectrometry-based protein‒protein interaction techniques and their applications in studies of DNA damage repair 作者:Zhen CHEN, Junjie CHEN 摘要:蛋白质作为主要的生物功能分子往往通过相互作用形成复合体和动态的互作网络来行使其功能。这些互作网络使得细胞和器官能够正常行使功能,并有效地应对外界环境的刺...