Xing Kang et al, Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors, Cell (2025). DOI: 10.1016/j.cell.2025.04.012. Reciprocal interaction between extrachromosomal DNA maintenance and DNA ...
The DNA-damage response in human biology and disease. Nature. 2009;461(7267):1071-1078. doi:10.1038/nature08467 Oksenych V, Kainov DE. DNA Damage Response. Biomolecules. 2021; 11(1):123. doi.org/10.3390/biom110 zh.wikipedia.org/wiki/% O'Connor MJ. Targeting the DNA Damage Response in...
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response. Mol Cell. 2017 Jun 15;66(6):801-817. Prithviraj Bose, et al. Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights. Pharmacol Ther. 2014 Sep;143(3):323-36. Marc-Olivier Turgeon, ...
DNA是一种相对稳定的有机分子,但仍然会受到来自各种外源性压力(例如紫外线照射、电离辐射和化学暴露)以及内源性因素(例如复制错误、细胞代谢和氧化应激)的不断攻击,最终会导致单链DNA断裂(SSB)或双链DNA断裂(DSB)。 因此,细胞进化出了一个复杂的生化途径系统来处理这种威胁,统称为DNA损伤应答(DNA-damage response,...
Das C, Adhikari S, Bhattacharya A, et al. Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer [published online ahead of print, 2023 Jan 18]. Cancer Res. 2023;CAN-22-3015. doi...
The DNA damage response is a network of cellular pathways that sense, signal and repair DNA lesions. Surveillance proteins that monitor DNA integrity can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage, to prevent the generation of potentially deleterious mutations....
DNA damageDNA repair mechanismsGenotoxic stressPlantsSeveral environmental and endogenous factors create a variety of lesions in the genome of an organism. These lesions could potentially be genotoxic and might lead to mutations, which could be lethal. All organisms exhibit a prompt response against ...
In response to DNA damage, ATM and/or ATR trigger the activation of a checkpoint that leads to cell cycle arrest or delay. Checkpoint pathways are characterized by cascades of protein phosphorylation events (indicated with a "P") that alter the activity, stability, or localization of the ...
但频繁接触 X 射线会带来健康隐患,它能直接 “攻击” 细胞中的 DNA,造成多种损伤,其中最严重的就是 DNA 双链断裂(DSBs) 。要是这些损伤没得到及时修复,细胞的基因就可能发生突变,进而引发各种功能紊乱。为了应对这种情况,细胞进化出了一套精密的防御机制 ——DNA 损伤应答(DDR),它就像细胞内的 “维修队”,能...
为了确保生物的存续,代偿细胞内可能发生的不同程度和类型的DNA损伤,生命演化发展出了一套专门的机制,称为DNA损伤响应(DNA Damage Response,DDR),来维护基因组的完整性。DDR通过协调针对不同损伤类型的多种机制和多层次的信号级联,确保遗传信息能够长期保存。目前,在生物体内至少发现了五种主要的DNA修复途径,包括碱基...