Definition DNA damage response genes encompass all genes that encode proteins required for either direct or indirect response to DNA damage. The proteins encoded by these genes either act to help repair the damaged DNA within replicating cells or if damage is sufficient, to activate cell cycle ...
Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, i...
Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, i...
大多数DNA修复因子在衰老细胞中有所下调,导致修复活性降低,尤其是同源修复途径活性的降低。这表明,清除和降解失败的、潜在不稳定的修复中间产物(如CCF),可能是一种保护基因组完整性或抑制过度DNA损伤反应(DNA damage response, DDR)信号的机制。 表1 细胞质DNA的分子标记物 CCF 与疾病治疗 除了上述CCF和SASP的功能...
γH2AX和CCF的关联表明CCF是DNA修复过程的副产物。大多数DNA修复因子在衰老细胞中有所下调,导致修复活性降低,尤其是同源修复途径活性的降低。这表明,清除和降解失败的、潜在不稳定的修复中间产物(如CCF),可能是一种保护基因组完整性或抑制过度DNA损伤反应(DNA dam...
1. Bala S C Koritala, et al. Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans. J Pineal Res. 2021 Feb 27;e12726. 2. Spencer J Collis, et al. Emerging links between the biological clock and the DNA damage response. Chromosoma. 20...
Importantly, human cancers are often deficient in the DNA damage response. Germline mutations in DNA damage response genes, such as ATM, NBS1, FANCD2, BRCA1, and BRCA2, can result in an increased susceptibility to cancer. Individuals who inherit a single mutant allele of, say, BRCA1, have...
[22] Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, et al. Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nature Genetics. 2017;49(1):10-6. [23] Wengner AM, Scholz A, Haendler B. Targeting DNA Damage Response in Prostate...
11月6日,上述团队在Cell Reports上发表题为SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response研究论文,利用哺乳动物细胞双杂交系统和荧光素酶报告基因系统,筛选和鉴定出一批潜在与TET2互作蛋白。其中,转录共激活子SNIP1(SMAD nuclear interacting protein 1) 是与TET2结合蛋白中荧...
1、Harper JW, Elledge SJ. The DNA damage response: ten years after.Mol Cell2007; 28:739-745. 2、Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.Annu Rev Biochem2010; 79:181-211. ...