Recently, FANCM was also found to play important roles in multiple DNA damage response pathways. Thus, here we take FANCJ, BRCA1 and FANCM as examples to further investigate how DNA damage response proteins regulate the centrosome. Our overall hypothesis is that DNA damage response proteins ...
The DNA damage response is a network of cellular pathways that sense, signal and repair DNA lesions. Surveillance proteins that monitor DNA integrity can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage, to prevent the generation of potentially deleterious mutations....
SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation The authors show that the SUMO protease SENP6 plays an essential role in maintaining genome integrity by disassembling SUMO2/3 polymers from DNA damage response proteins, thereby preventing the...
The key regulators of the checkpoint pathways in the mammalian DNA damage response are the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases. Both of these proteins belong to a structurally unique family of serine-threonine kinases characterized by a C-terminal ...
在本研究中，研究者发现crwn1 crwn2 双突变体中损伤应答（DNA damage response，DDR）系统被激活，且CRWN1和CRWN2均能定位于DNA双链断裂点 (DNA double strand break，DSB) 位点。正常条件下，CRWN1/2蛋白主要分布在细胞核周缘。当DNA受到损伤，CRWN1/2在细胞内形成动态的表面无膜状的颗粒小体结构。纯化的CRW...
The DNA damage response is a hierarchical process. DNA damage is detected by sensor proteins such as the MRN complex that transmit the information to transducer proteins such as ATM and ATR, which control the damage response through the phosphorylation of effector proteins. The extent of the DNA...
[6] Zhou BB, Elledge SJ 2000. The DNA damage response: Putting checkpoints in perspective [J]. Nature 408: 433–439. [7] Matsuoka S, Huang M, Elledge SJ 1998. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase [J]. Science 282: 1893–1897. ...
DNA damage sensor proteins and DNA damage signaling proteins can both be targeted with a range of anticancer agents. Drug Targeting of DNA Damage Sensor Proteins DDR is essential for the activation of repair pathways and cell survival. DDR sensor proteins, which respond to a wide variety of DNA...
1 Damaged DNA must be repaired to maintain genomic integrity via processes that evolved by the cell type, collectively termed the DNA damage response (DDR).2 DDRs are orchestrated by an incredibly complex network of proteins that sense and assess the type and extent of damage, decide between ...
[24]Moumen, A., et al., hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell, 2005. 123(6): 1065-78. [25]Dintilhac, A. and J. Bernues, HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. J ...