2023年12月4日，徐州医科大学附属医院普外科任泽强/张蓬波团队在Molecular Cancer（IF=37.3）发表文章hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma。结果显示，作者在胰腺导管腺癌预后...
但是有关circRNA对PDAC中DNA损伤调控的研究尚未见报道。 2023年12月4日,徐州医科大学附属医院普外科任泽强/张蓬波团队在Molecular Cancer(IF=37.3)发表文章hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic du...
IMPDH2 scored as a common interactor between PARP1 and TOP2A (Fig.4Aand Supplementary Data5). This evidence strengthened our hypothesis of a possible role of chromatin-associated IMPDH2 in the DNA damage response, given that PARP1 and TOP2A are chromatin master regulators of the DNA ...
但是有关circRNA对PDAC中DNA损伤调控的研究尚未见报道。 2023年12月4日,徐州医科大学附属医院普外科任泽强/张蓬波团队在Molecular Cancer(IF=37.3)发表文章hsa_circ_0007919 inducesLIG1transcription by binding toFOXA1/TET1to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal a...
1.It is becoming increasingly evident that many, if not all, tumor types contain a subset of cells that are labeled positive for markers of DNA damage response (DDR) . The DNA damage-induced ataxia telangiectasia mutated (ATM)/ataxia...
通过WebGestalt 网站对 ceRNA 网络中的 37 个 mRNA 进行 GO 功能分析和 KEGG 通路富集分析,预测这些基因在 HCC 预后中的作用。GO 功能分析结果显示,37 个 mRNA 主要参与生物调节(biological regulation)、代谢过程(metabolic process)和...
Ubiquitin signaling plays a key role during the DNA damage response in protein recruitment and protein interactions. Deubiquitinating enzymes (DUBs) deconjugate ubiquitin from ubiquitylated substrate proteins to control their activity and stability and are shown to regulate various biological processes. DUBs...
Here, we report a mechanism through which gastric cancer cells in response to radiochemotherapy were reprogrammed into gastric cancer stem cell-like cells. In this mechanism, radiochemotherapy triggers DNA damage response accompanied by elevated levels of EID3, a typical DNA repair gene, which inter...
DNA damage and subsequent activation of the DNA damage response (DDR) occurs in cardiomyocytes of heart failure (HF) patients13,14,15. Moreover, recent studies suggest that DNA damage is induced in cardiomyocytes during transverse aortic constriction (TAC)-induced heart failure development16,17. In...
3e). Using iPSC and CM extracts in western blots, we found markedly reduced activation (reflected in phosphorylation) of several DNA damage response components, like p53, CHK1/2, and γH2A.X in mutant cells, as well as inefficient PARP1 cleavage (Supplementary Fig. 3d, k). Moreover, ...