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DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANC 专利名称：DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER 发明人：ASHWORTH, Alan,JACKSON,Stephen,MARTIN, Niall,SMITH, Graeme 申请号：EP04798705.2 申请日：20041130 公开号：EP1684736B1 公开日：20110824 专利内容由知识产权出版社提供 摘要：The ...
A PARP1–BRG1–SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. 47, 8563–8580 (2019). CAS Google Scholar Ocampo, A. et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 167, 1719–1733.e12 (2016). ...
To overcome the harmful effects of DNA damage, cells have various systems such as DNA repair mechanisms, damage tolerance pathways, cell cycle checkpoints, and cell death pathways. These systems work together to repair or tolerate DNA damage, ensuring the overall survival and functionality of cells...
Impact of exposure to ultraviolet-B (UVB) radiation on keratinocytes; Main repair mechanism for UVB-induced DNA damage in mammalian cells; Finding of a study made on mice which are deficient in nucleotide excision repair.FrantzSimonEBSCO_AspNature Reviews Molecular Cell Biology...
DNA (redirected fromDNA repair) Thesaurus Medical Legal Encyclopedia Wikipedia DNA A. adenine T. thymine C. cytosine G. guanine DNA (dē′ĕn-ā′) n. A nucleic acid that carries the genetic information in cells and some viruses, consisting of two long chains of nucleotides twisted into a...
K. DNA charge transport as a first step in coordinating the detection of lesions by repair proteins. Proc. Natl Acad. Sci. USA 109, 1856–1861 (2012). This study elegantly describes how DNA damage can be efficiently recognized by collaboration between DNA repair proteins that are able to ...
英文名称 DNA Damage/DNA Repair compound Library 产品介绍 描述及优势 •独特的685种具有生物活性的小分子化合物,用于DNA损伤和修复研究 •针对PARP,ATM / ATR,拓扑异构酶,DNA / RNA合成等靶点 •某些化合物已获得FDA批准 •结构多样,具有药用活性,可透过细胞 •提供丰富的文档信息,包括结构,IC50和...
7.Olive PL,Banath JP,Durand RE.Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the“comet”assay [J] Radiat Res.1990 Apr,122(1):86～948.Kent CR,Eady JJ,Ross GM,etal.The comet moment as a measure of DNA damage in the comet assay [J...
关键词:肿瘤;DNA 损伤修复;放疗;放射敏感性;机制 中图分类号:Q691 文献标识码:R 文章编号:1004-714X(2020)04-0442-04 DNA damage repair and radiosensitivity of tumor YANG Siqi1,YAO Yi1,2,SONG Qibin1,2,ZHENG Sihao2,GAO Yanjun1,2,WU Bin1 1. Cancer Center, Wuhan University ...