DNA damage response and repair (DDR) is responsible for ensuring genomic integrity. It is composed of intricate, complex pathways that detect various DNA insults and then activate pathways to restore DNA fidelity. Mutations in this network are implicated in many malignancies but can also be ...
27.Gros L, Saparbaev MK, Laval J. 2002. Enzymology of the repair of free radicals-induced DNA damage. Oncogene. 21(58):8905-8925.28.You J, Wang M, Lee S. 2003. Biochemical Analysis of the Damage Recognition Process in Nucleotide Excision Repair. J. Biol. Chem.. 278(9):7476-7485....
Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the current knowledge of DNA damage signalling and repair inhibitors, their molecular and cellular ...
1、DNA repair pathways as targets for cancer therapyu DNA-damage agents in cancer treatmentu Efficient repair of chemotherapy lesionsu DNA repair inhibitors in combination therapyContentsDNA-damage agents 1. Radiotherapy and radiomimetics u Ionizing radiation can cause single-strand breaks (SSBs) and ...
A PARP1–BRG1–SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. 47, 8563–8580 (2019). CAS Google Scholar Ocampo, A. et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 167, 1719–1733.e12 (2016). ...
K. DNA charge transport as a first step in coordinating the detection of lesions by repair proteins. Proc. Natl Acad. Sci. USA 109, 1856–1861 (2012). This study elegantly describes how DNA damage can be efficiently recognized by collaboration between DNA repair proteins that are able to ...
DNA Damage Repair The use of inhibitors to DNA repair mechanisms is a potential therapeutic target. Such agents have been developed such as inhibitors of the single-stranded break DNA repair enzyme poly(ADP-ribose) polymerase 1 [33]. View chapter Review article Targeting homologous recombination rep...
DNA (redirected fromDNA repair) Thesaurus Medical Legal Encyclopedia Wikipedia DNA A. adenine T. thymine C. cytosine G. guanine DNA (dē′ĕn-ā′) n. A nucleic acid that carries the genetic information in cells and some viruses, consisting of two long chains of nucleotides twisted into a...
2004. Interplay between DNA replication, recombination and repair based on the structure of RecG helicase. Philos Trans R Soc Lond B Biol Sci 359: 49–59. (119)Gupta S, Yeeles JTP, Marians KJ. 2014. Regression of replication forks stalled by leading-strand template damage: I. Both RecG...
However, intrinsic DNA damage response and repair provide tumour cells with some protection. The pathological DSBs caused by IR and topoisomerase II inhibitors are mainly repaired by NHEJ, which requires DNA-dependent protein kinase (DNA-PK), comprising the DNA-dependent protein kinase catalytic ...