1、DNA damage, repair and recombinationDNA损伤、修复和重组,Chapter 6,Damage and Mutation (损伤和突变,DNA damage is simply a chemical alteration to DNA. DNA损伤仅是DNA分子的化学改变 A mutation is a heritable permanent change in the base sequence of DNA. DNA碱基序列水平上的永久性可遗传的改变,...
10.5DNA损伤与修复 DNA Damage and Repair 这门课程主要包括四个方面的内容:1、生物大分子的结构与功能:包括蛋白质、核酸、酶、聚糖等的分子组成,分子结构,结构与功能的关系及主要理化性质。2、物质代谢及其调节:包括糖、脂质、氨基酸、核苷酸、非营养物质代谢及物质代
10.5DNA损伤与修复 DNA Damage and Repair(下) 1093 播放芭比衣橱 收藏 下载 分享 手机看 登录后可发评论 评论沙发是我的～选集(126) 自动播放 [1] 1绪论 2326播放 03:52 [2] 2.1氨基酸的结构Structur... 970播放 05:42 [3] 2.2氨基酸的分类与性质Class... 651播放 06:56 [4] 2.2...
(1997) Formation, prevention and repair of DNA damage by iron/hydrogen ... E Henle,S Linn - 《Journal of Biological Chemistry》 被引量: 0发表: 1997年 Formation, Prevention, and Repair of DNA Damage by Iron\\/Hydrogen Peroxide Henle ES, Linn S (1997) Formation, prevention, and repair ...
DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosome...
DNAdamage,repair,andrecombination F1MutagenesisF2DNAdamageF3DNArepairF4Recombination F1Mutagenesis 1.Mutation MutationareheritablepermanentchangesinthebasesequenceofDNA.1.1Pointmutation:isthesimplestmutation-asinglebasechange.Transition:purineorpyrimidineisreplacedbytheother AGTC F1Mutagenesis 1Mutation Transversion:a...
DNAdamage,repairandmutation 第一节DNA损伤 一、自发性损伤（spontaneousmutations）1、DNA复制错误校正后的错配率仍约在10-10左右2、互变异构(烯醇式-酮式结构互变)3、自发性的化学变化脱嘌呤和脱嘧啶脱氨（基）(deamination)作用 （1）脱嘌呤和脱嘧啶 •糖苷键断裂,嘌呤和嘧啶从DNA链的核糖磷酸骨架上脱落 （...
DNA damage is an abnormal chemical structure in DNA which can cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA mo...
(NER). A DNA repair pathway that recognizes and removes bulky DNA lesions such as those formed by UV light. NER involves damage recognition, nicks flanking the lesion and removal of the damaged DNA strand, filling in the gap by DNA polymerase and ligation of the nicks to restore the intact...
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, ...