DNAdamage,repair,andrecombination F1MutagenesisF2DNAdamageF3DNArepairF4Recombination F1Mutagenesis 1.Mutation MutationareheritablepermanentchangesinthebasesequenceofDNA.1.1Pointmutation:isthesimplestmutation-asinglebasechange.Transition:purineorpyrimidineisreplacedbytheother AGTC F1Mutagenesis 1Mutation Transversion:a...
DNAdamage,repairandmutation 第一节DNA损伤 一、自发性损伤（spontaneousmutations）1、DNA复制错误校正后的错配率仍约在10-10左右2、互变异构(烯醇式-酮式结构互变)3、自发性的化学变化脱嘌呤和脱嘧啶脱氨（基）(deamination)作用 （1）脱嘌呤和脱嘧啶 •糖苷键断裂,嘌呤和嘧啶从DNA链的核糖磷酸骨架上脱落 （...
DNA damage is an abnormal chemical structure in DNA which can cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA mo...
Repair of DNA Damage by Iron / Hydrogen Peroxide Formation, prevention and repair of DNA damage by iron\hydrogen peroxide. J Biol Chem 272, 19095-19098.Henle, E. S. and Linn, S. (1997) Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide. J. Biol. ... ES Henle...
(NER). A DNA repair pathway that recognizes and removes bulky DNA lesions such as those formed by UV light. NER involves damage recognition, nicks flanking the lesion and removal of the damaged DNA strand, filling in the gap by DNA polymerase and ligation of the nicks to restore the intact...
DNA损伤与修复机制 | DNA damage and repair DNA损伤修复功能异常是肿瘤发生发展的重要特点之一,突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能...
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, ...
3. DNA损伤的类型 3.1 内源性DNA损伤3.2 外源性DNA损伤 4. DNA损伤与DNA变异 5. DNA损伤应答（DDR）途径 5.1 DNA修复机制5.2 细胞周期停滞与细胞凋亡 6. DNA损伤与疾病 7. 与DNA损伤修复相关的重组蛋白 1. 什么是DNA损伤？DNA损伤是指任何偏离其原始双螺旋结构的改变。所有细胞生物都会发生DNA损伤。2....
The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
Normal cells are able to repair these lesions with fidelity or by introducing errors. Base excision (BER) and nucleotide excision (NER) repair are error-free processes acting on the simpler forms of DNA damage. A specialized form of BER involves the removal of mismatched DNA bases occurring as...