35.Sánchez-Pérez I. 2006. DNA repair inhibitors in cancer treatment. Clin Transl Oncol. 8(9):642-646.36.Madhusudan S, Hickson ID. 2005. DNA repair inhibition: a selective tumour targeting strategy. Trends in Molecular Medicine. 11(11):503-511.37.PLUMMER E. 2006. Inhibition of poly(AD...
Clinical importance of DNA repair inhibitors in cancer therapy. Memo—Magazine of European Medical Oncology . 2009; 2 (1):9–14.Hosoya N, Miyagawa K (2009) Clinical importance of DNA repair inhibitors in cancer therapy. Memo 2(1):9-14...
Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.A·阿什沃斯G·史密斯N·马丁S·杰克逊
treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.申请人：KUDOS PHARM LTD,CANCER RES INST 地址：GB,GB 国籍：GB,GB 代理机构：Sutcliffe, Nicholas Robert 更多信息请下载全文后查看 ...
stress as a consequence of oncogene-induced growth signals or hypoxia-induced replication arrest. We propose that DNA repair inhibitors could be used to prevent the repair of replication lesions present in tumour cells and convert them into fatal replication lesions that specifically kill cancer cells...
突变或未知应突变使用PARP 抑制剂治疗，取决于单独 NHT治疗的早期进展的危险因素，并且需与患者进行共同决策 原文阅读：https://www.urotoday.com/conference-highlights/eau-2024/eau-2024-prostate-cancer/151067-eau-2024-parp-inhibitors-only-for-patients-with-alterations-in-dna-repair-genes-no.html ...
Amplifying tumour-specific replication lesions by DNA repair inhibitors — a new era in targeted cancer therapy. Eur. J. Cancer 44, 921–927 (2008). Article CAS PubMed Google Scholar Hegnauer, A. M. et al. An. N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53...
1. Targeting DNA repair pathway in cancer:Mechanisms and clinical application. MedComm (2020). 2021 Dec; 2(4):654–691. 公众号内回复“肿瘤免疫”或扫描下方图片中的二维码免费下载《小药说药肿瘤免疫全集》的PDF格式电子书! 公众号已建立“小药说药专业交流群”微信行业交流群以及读者交流群,扫描下方小编...
that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of DNA repair mechanisms as methylgua......
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