We showed that resistance to anticancer drugs alters the electrophoretic mobility in a permanent manner, even lasting without any exposure to anticancer agents for a long time period. We also studied the cellular morphologies of adherent cells where the cellular invaginations and protrusions were ...
In addition, that of OCLN was increased by resistance to CDDP in human lung adenocarcinoma RERF-LC-MS and PC-3 cells (Fig. 1E). These results indicated that the resistance to anticancer drugs increased the expression and tight junctional localization of OCLN in A549 cells. Figure 1 Elevation...
Increasing epidemiological evidence, as well as a better understanding of the mechanisms which link toxicants to the development of cancer suggest that exposures to some environmental chemicals found in common products may lead to an increased risk of developing cancer. More recently, the role of exp...
W. Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Res. 30, 3223–3232 (2010). CAS PubMed Google Scholar Lord, R. V. et al. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non...
which contribute to resistance to anticancer drugs. CSCs can also undergo EMT transition to better migrate to the surrounding tissues [265]. With the concept of CSCs evolving, researchers have found that the abnormalities in TRIM family activities function in the acquisition and maintenance of the ...
Anticancer drug for overcoming resistance to agents and anticancer drugs effect enhancer 来自 百度文库 喜欢 0 阅读量: 14 申请(专利)号: JP20000146733 申请日期: 2000-05-18 公开/公告号: JP4041642B2 公开/公告日期: 2008-01-30 申请(专利权)人: 金子 昇 发明人:...
Because multiple mechanisms may contribute to resistance to every anticancer drug, it is not surprising that initial or acquired drug resistance is observed after treatment of most cell populations. TABLE 19–1 Cellular mechanisms associated with resistance to anticancer drugs.* FIGURE 19–1 Multiple ...
Oral delivery of anticancer drugs: Challenges and opportunities The present report focuses on the various aspects of oral delivery of anticancer drugs. The significance of oral delivery in cancer therapeutics has been h... K Thanki,RP Gangwal,AT Sangamwar,... - 《Journal of Controlled Release ...
of an ABC transporter to thereby overcome resistance to anticancer drugs; cancer cells useful in screening such drugs; and an anticancer drug efficacious even against such a cancer as having acquired resistance to anticancer drugs.doi... S Tsukahara,Y Imai,Y Sugimoto - US 被引量: 3发表: 2007...
DU145R80 cells acquired resistance to spontaneous apoptosis under adhesion and anoikis conditions and overexpressed Bcl-2 and c-Myc Resistance to anticancer drugs is often related to activation of prosurvival/antiapoptotic pathways. Using AnnexinV staining and cytofluorimetric analysis of adherent cells pe...