Cell Communication and SignalingDean M: ABC Transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia 14(1): 3-9, 2009.Dean M. ABC Transporters, drug Resistance, and Cancer Stem Cells. J Mammary Gland Biol Neoplasia 2009; 14(1): 3-9....
In CSCs, cell death mechanisms are controlled via modulation of cell cycle. This strategy, which also contributes to EMT, creates resistance. While conventional cancer therapy mainly targets cancer cells relying on their rapid proliferation, slow cycling-cancer cells are not affected [12]. CSCs main...
因此,一直以来STAT3都被认为是癌症等疾病的治疗靶点。但不幸的是,靶向STAT3的小分子药物由于特异性较差等原因难以寻找【2】。 2019年11月11日,美国密歇根大学的王少萌教授课题组在Cancer Cell杂志上发表了题为A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo的论文...
squamous cell carcinoma(鳞状细胞癌) adeno-squamous transition(腺鳞转型) KRAS inhibitors(KRAS抑制剂) resistance(耐药性) oncogenic KRAS(致癌性KRAS) 研究背景 腺癌向鳞状细胞癌的组织学转变(腺鳞转型,AST)常在肺癌患者接受癌症治疗过程中观察到。 KRAS突变是肺腺癌患者中最常见的驱动突变之一,KRAS G12C和G12D...
2018年7月3日,卡罗林斯卡医学院曹义海研究组,华中科技大学同济医学院聂国辉研究组及上海中医药大学李琦研究组合作在Cancer Cell(IF=23)在线发表题为“Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance”的研究论文,该论文描述了AAD触发的脂质依赖性代谢重编程,作为AAD抗性的替代机制。出乎意料的是,脂肪和...
Cancer Drug Resistance is a peer-reviewed journal led by Editor-in-Chief Godefridus J. (Frits) Peters, covering drug resistance research on breast cancer, lymphatic cancer, hematological malignancies, thyroid cancer, lung cancer, stomach cancer, esophage
the integration of various pathways involved in the control of stem cell fate across tissues; for example, CYP26, a primary retinoid-inactivating enzyme through retinoid and Hedgehog pathways, limits the retinoic acid concentration, therefore leading to drug resistance in the stem cell niche [171]....
Resistance to chemotherapy, the underlying cause of treatment failure, presents an enormous problem. 40 percent of operable cancers and 80 percent of inoperable cancers are drug-resistant (Vogel). After the selection for resistance to a ... E. McMurray - 《Microreviews in Cell & Molecular Biolog...
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果; • 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物; • 与世界各大制药公司及知名科研机构建立了长期的合作。 关键词:CancerDrugResistance(肿瘤耐药)抑制剂 ...
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses1. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer ‘persister’ cells2,3,4. The persister cell pool constitutes a reservoir from...