This study identified Circ-Spen as a positive regulator of mouse bone marrow mesenchymal stem cell (mBMSC) viability. The expression of Circ-Spen was markedly increased in ERβ/ mice femurs tested by RT-qPCR. Moreover, Circ-Spen exhibited an enhanced expression during the bon...
aExperiment schematic. Single-cell RNA sequencing was performed on total and depleted (CD45−/Ter119−) bone marrow cells.bProjection of data onto two dimensions usingt-distributed stochastic neighbor embedding (tSNE63) indicates that bone marrow population structure is preserved in biological repli...
a, FACS plots of adult mouse bone marrow (left) and representative cytospin of FACS-sorted adult mouse bone marrow (right). The populations sorted for scRNA-seq are indicated in red. b, Schematic summary of the cellHarmony algorithm. c, cellHarmony-assigned ICGS states of combined wild-type...
Reconstitution of T cells by bone marrow transplantation, prolonged the survival, reduced proinflammatory responses, restored neuroprotective factors and inhibited M1 microglial activation [18, 27]. In ALS patients, peripheral blood cell counts of CD3, CD4, CD8 and CD3+CD56+ T cells, natural killer...
Also, since this was a single-cell RNAseq dataset, it enabled us to further refine the localization and characterization of dysfunctional T cell and monocytic lineages within these tumors. Populations enriched in the human tumors relative to surrounding bone marrow (involved) included T helper (Th...
CD4+ T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of several effector subtypes that exhibit disti
Microglia were sorted from fluorescence reporter mice after pMCAO or sham surgery and then subjected to single-cell RNA sequencing analysis. Various methods, including flow cytometry, RNA in situ hybridization, immunohistochemistry, whole-brain imaging, and bone marrow transplantation, were also employed...
Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet. 1996;347:649–53. Article CAS Google Scholar Pantel K, Alix-Panabieres C. Liquid biopsy and minimal residual disease - latest advances and ...
1 A multi-omic analysis of primary mouse bone marrow neutrophils during aging and with respect to sex (continued). a, Table of significant ‘omic’ features as a function of organismal age and sex in our datasets based on DEseq2 (RNA-seq) or limma (Metabolomics and lipidomics), at FDR...
Multiple myeloma is a bloodcancerthat occurs in the bone marrow. It is caused by the proliferation of plasma cells,immune cellsresponsible for producing antibodies. It is aheterogeneous disease, meaning that it can present in different ways and have different responses to treatment. To meet the m...