Results A prognostic model was established based on 8 MHC-I-related genes, and the predictive capacity of the model was accurate. Immune analysis results revealed that patients classified as high-risk had lower levels of immune cell infiltration and impaired immune function. The low-risk group ...
MHC,就是主要组织相容性复合体 (major histocompatibility complex),是存在于大部分脊椎动物基因组中的一个基因家族,与免疫系统密切相关,其中人类的MHC糖蛋白,又称为人类白血球抗原(英语:human leukocyte antigen,简称HLA)。MHC区域位于位于6号染色体上(6p21.31),hg38基因组中29Mb 到 33Mb的位置。这个地方具有高基因...
重组人MHC class I chain-related基因 A 英文名称: 总访问: 1044 国产/进口: 进口 半年访问: 16 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: 2 µg,货号:PRO-367 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 700 立即询价 电话咨询 ...
At present, one of the best-characterized activating receptors is NKG2D, which promotes the NK-mediated lysis of target cells by binding to a family of cell surface ligands encoded by the MHC class I chain-related (MIC) genes, among others. The goal of this study was to describe the ...
MouseMHC=H-2 1996NobelPrize(MHCrestriction)MHC OrganizationandStructureofMHCGenesandProducts 1.OrganizationofMHCgenes2.ProductsofMHCclassIandMHC classIIgenes---HLAmolecules3.Immunefunctionrelatedgenes MHC 1.OrganizationofMHCgenes H-2K I S AβAαEβEαC4BfC2DL IAIE Ⅰ ⅡⅡ Chromosome17(mouse)
A. et al. Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes. Nat. Biotechnol. 33, 1152–1158 (2015). Article CAS PubMed PubMed Central Google Scholar Kawaguchi, S., Higasa, K., Shimizu, M., Yamada, R. & Matsuda, F. HLA-HD: an accurate HLA typing...
Classes I and II are shaded grey. Proposed MS-related genes are highlighted with red stars. Positions and gene symbols are from UCSC (build 36). Full size image Genetic similarity among couples was not ubiquitous throughout class I; a locus of dissimilarity was found at 31.0 Mbp, within a...
autophagy,butCD86wassignificantlyaltered,knockdownofautophagy-relatedgenes Atg5, Atg7 or Beclin 1 also increased MHC-I antigen expression by macrophages .In B16cell, rapamycin did not show inhibitory effect, but synergized with IFN-γ to further upregulate MHC-I antigen expression On the other hand...
2M). Furthermore, we measured the level of antibodies carrying the idiotype of the knock-in or possibly related members of the same idiotypic family, and again this indicated comparable levels between the two groups (Fig. S1F–H). Immunofluorescence microscopy of spleen sections confirmed ...
MHC class I chain-related gene A(MICA; GenBank accession:NM_001177519), discovered almost 30 years ago9, encodes a polymorphic non-conventional MHC-encoded class I molecule10. TheMICAgene is located, within the HLA complex, 46 kb centromeric to theHLA-Blocus9. Close to 400MICAalleles ...