HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ ...
The MHC class I-like Zn-뱉-glycoprotein gene maps to mouse chromosome 5The MHC class I-like Zn-뱉-glycoprotein gene maps to mouse chromosome 5biology and medicine, basic studiesmiceanimal cellshistocompatibility complexgeneschromosomes...
Evolution of the major histocompatibility complex: a hundred-fold amplification of MHC class I genes in the African pigmy mouse Nannomys setulosus. Immunogenetics. 1992; 37:29-38. [PubMed: 1428009]Delarbre C, Jaulin C, Kourilsky P, Gachelin G: Evolution of the major histocompatibility ...
The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products expressed by their host. Transgenic and gene knock-out mice have provided conclusive evidence that MHC class I genes control specificity and tolerance of NK cells. The article...
Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6 p pBackground/p pThe mouse has more than 30 itMajor histocompatibility complex /it(itMhc/it) class Ib genes, most of which exist in the itH2 /itregion of c... ...
Mouse anti Mouse MHC Class I H-2Kb antibody, clone AF6-88.5 recognizes the H-2Kb determinant present on all nucleated cells of mice expressing this MHC class I haplotype. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections...
The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes— M4, M5 , and M6 —which are orthologous between the two species. M4 and M6 are pseudogenes in the ...
The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number...
Mouse anti Sheep MHC Class I antibody, clone VPM19 recognizes the ovine homologue of the human MHC Class I, a monomorphic determinant expressed on the heavy chain of sheep MHC Class I, (OLA Class I).The major histocompatibility complex (MHC) is a cluster of genes that are important in the...
The class I genes of the major histocompatibility complex of the mouse can be divided into two categories: those encoding the transplantation antigens and those encoding the Qa and Tla antigens. The inbred BALB/c mouse has 28 potential Qa/Tla genes. The sites of tissue expression, developmental...