HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in l...
HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in or...
Genes, MHC Class IAuthor information: (1)Department of Immunology, Institut Pasteur, Paris, France.doi:10.1007/BF00163965J M DrezenJ BarraC BabinetD MorelloSpringer-VerlagImmunogeneticsDrezen, J.M., Barra, J., Babinet, C. and Morello, D. (1994) MHC class I genes are not imprinted in the...
The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products expressed by their host. Transgenic and gene knock-out mice have provided conclusive evidence that MHC class I genes control specificity and tolerance of NK cells. The article...
Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6 p pBackground/p pThe mouse has more than 30 itMajor histocompatibility complex /it(itMhc/it) class Ib genes, most of which exist in the itH2 /itregion of c... ...
et al. Mice lacking all conventional MHC class II genes. Proc. Natl Acad. Sci. USA 96, 10338–10343 (1999). CAS PubMed PubMed Central Google Scholar Kobata, A. The third chains of living organisms-a trail of glycobiology that started from the third floor of building 4 in NIH. Arch...
Intriguingly, direct comparison of microglia in the 3xTg-D and 3xTg-S groups identified only five genes that were significantly modulated by SCDi in the 3xTg strain, and all five of these were MHC class I (MHC-I) genes: H2-D1, H2-K1, H2-T23, H2-Q6, and H2-M3 (Fig. 5i). ...
MHC-antigensstreptozotocincytotoxicityT cellsRat insulinoma cells clone 5AH-B, were transfected by electroporation with the gene encoding the mouse major histocompatibility complex class I antigen H-2K b , whereupon stable transfectants were selected and analysed. Data from flow cytometric analyses using...
Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex. In contrast to well-studied "classical" class I genes of the major histocompatibility complex (MHC), the biology of nonclassical class I genes remains larg... Y Obata,Y Satt...
This recognition depends on CD4+ T cells and their direct interaction with surface-expressed MHC class II molecules complexed with antigen. We have developed a series of mouse lines that do not express mouse FIX or mouse MHC II, but instead express human FIX genes and humanized MHC II. The ...