HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in or...
Preimplantation mouse embryos express Mhc class I genes before the first cleavage division. Immunogenetics 1993, 38 : 35–40.Sprinks MT, Sellens MH, Dealtry GB, Fernandez N (1993) Preimplantation mouse embryos express Mhc class I genes before the first cleavage division. Immunogenetics 38: 35–...
The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products expressed by their host. Transgenic and gene knock-out mice have provided conclusive evidence that MHC class I genes control specificity and tolerance of NK cells. The article...
We report the fine mapping of the H2-M class I gene cluster, which includes the previously reported M4-M6, the M1 family, the M10 family, and four additional class I genes. All but two of the H2-M class I genes are conserved among haplotypes H2 <sup> k </sup>, H2 <sup> b </...
et al. Mice lacking all conventional MHC class II genes. Proc. Natl Acad. Sci. USA 96, 10338–10343 (1999). CAS PubMed PubMed Central Google Scholar Kobata, A. The third chains of living organisms-a trail of glycobiology that started from the third floor of building 4 in NIH. Arch...
et al. Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation. J. Exp. Med. 213, 517–534 (2016). Article PubMed PubMed Central Google Scholar Kwon, K. et al. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center ...
Structure, function, and evolution of mouse TL genes, nonclassical class I genes of the major histocompatibility complex. In contrast to well-studied "classical" class I genes of the major histocompatibility complex (MHC), the biology of nonclassical class I genes remains larg... Y Obata,Y Satt...
Chicken MHC Class II genes, also known as the B-L subregion, of the chicken MHC encode cell surface glycoproteins that are homologous to mammalian Class II antigens. B-L antigens are structurally similar to mammalian Class II molecules in that they are noncovalently bound dimers of one ...
Characterization, Polymorphism, and Evolution of MHC Class II B Genes in Birds of Prey During the last decade, the major histocompatibility complex (MHC) has received much attention in the fields of evolutionary and conservation biology becau... M Alcaide,SV Edwards,JJ Negro - 《Journal of Mole...
dichotomous subdivision of an epithelial terminal unit 5.09 7.32E-04 1.21E-02 antigen processing and presentation of exogenous peptide antigen via MHC class Ia 5.17 2.53E-03 3.36E-02 defense response to tumor cella 4.98 1.60E-03 2.34E-02 cerebrospinal fluid circulation 5.11 3.27E-04 6.00E-03 ...