We have developed a semi-nested PCR assay which measures gene conversion in mouse MHC class genes. Detectable frequencies occur in DNA from sperm, but not in somatic DNA, such as liver or fibroblast DNA. The frequency of gene conversion events in MHC class II genes varies strongly from one ...
Generation of the MHC class II+/Ii- phenotype on tumor cells by Ii-RGC or Ii-RNAi leads to a potent tumor cell immunotherapy 6047 RNAi is a potent method to inhibit specific gene expression. This method has been evaluated as a potential tool to treat cancer, for example, to specifically ...
产品描述 概述 This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also ...
The products of the highly polymorphic genes known as the major histocompatibility complex (MHC) have been shown to play a major part in the control of several aspects of the immune response and of susceptibility to certain diseases. The major transplantation antigens are membrane proteins composed...
The polymorphic determinant represented by the mouse major histocompatibility complex class II (MHC Class II) is expressed by the immune cells bearing the specified alloantigens, like T and B lymphocytes, monocytes, dendritic cells, and macrophages. The antibody doesn’t react with the NOD H-2g7...
CD4也称为T4,为55 kD的单链I型跨膜糖蛋白,表达于大部分胸腺细胞、T细胞亚群和单核/巨噬细胞。CD4作为免疫球蛋白超家族的一员,可识别与MHC II类分子结合的抗原,参与细胞-细胞互作、胸腺分化和信号传导。CD4是HIV的主要受体,可与HIV gp120结合。CD4与IL-16也有相互作用。
CD4也称为T4,为55 kD的单链I型跨膜糖蛋白,表达于大部分胸腺细胞、T细胞亚群和单核/巨噬细胞。CD4作为免疫球蛋白超家族的一员,可识别与MHC II类分子结合的抗原,参与细胞-细胞互作、胸腺分化和信号传导。CD4是HIV的主要受体,可与HIV gp120结合。CD4与IL-16也有相互作用。
MHC Antigens Antigen References 1. Stallcup KC, et al. 1981. J. Immunol. 127:923 Gene ID 111364 View all products for this Gene ID UniProt View information about H-2 on UniProt.org Documentation Technical data sheet Certificate of Analysis Safety Data Sheet Reviews Review Thi...
(Extended Data Fig.5f), indicating DC lineage. They encompassed major histocompatibility complex II (MHC-II)−/lowand MHC-IIhighcells putatively corresponding to pre-DCs versus differentiated DCs, respectively. A decrease in the absolute numbers of most of DC types was observed in the spleen ...
IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. ...