Major histocompatibility complex (MHC) genes code for key proteins of the adaptive immune system, which present antigens from intra-cellular (MHC class I) and extra-cellular (MHC class II) pathogens. Because of their unprecedented diversity, MHC genes have long been an object of scientific ...
Metastatic clones of murine tumors that manifest impaired expression of class I MHC antigens do not induce an antitumor CTL activity. Transfection of H-2Kb genes into D122 carcinoma and B16 melanoma clones converted these cells to low metastatic immunogenic clones that can be used to protect in...
Here the authors characterise bone marrow cells from PRCA patients by single cell sequencing showing hyperactive CD8+ T cells, impaired erythropoiesis, increase of MHC-I proteins and antigen presentation associated genes in erythroid cells. Qi Hu Yang Liu Hsiang-Ying Lee ResearchOpen Access22 Nov ...
Our data support the notion that an extremely high rate of loci turnover is largely responsible for the limited diversity of the MHC class I genes in the cotton-top tamarin. 展开 关键词: Key words New world primates MHC Evolution Gene duplication ...
I. Watkins. 1996. The MHC class I genes of the rhesus monkey: different evolutionary histories of MHC class I and II genes in primates. J. Immunol. 156:4656.Boyson JE, Shufflebotham C, Cadavid LF, Urvater JA, Knapp LA, Hughes AL, Watkins DI. 1996. The MHC class I genes of the ...
The MHC class I genes of the New World primate, the cotton-top tamarin (Saguinus oedipus), are an exception to the high polymorphism and variability displayed by this multigene family. We report the isolation of the first two processed pseudogenes from the MHC region in primates. These two MH...
We cloned, sequenced and transfected the MHC class I genes from three other species of bone-chimeric primates (the saddle-backed tamarin, S. fuscicollis; the common marmoset, Callithrix jacehus; and the golden-headed lion tamarin, Leontopithecus rosalia) and a single species of a non-bone marro...
The classical MHC class I genes have been known to be highly polymorphic in various vertebrates. To date, putative allelic sequences of the classical MHC class I genes in teleost fish have been reported in several studies. However, the establishment of their allelic status has been hampered in...
The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes— M4, M5 , and M6 —which are orthologous between the two species. M4 and M6 are pseudogenes in the ...
We cloned, sequenced and transfected the MHC class I genes from three other species of bone-chimeric primates (the saddle-backed tamarin, S. fuscicollis; the common marmoset, Callithrix jacehus; and the golden-headed lion tamarin, Leontopithecus rosalia) and a single species of a non-bone ...