We analyzed the restriction fragment length polymorphism of class I and class II MHC genes in DNA from 20 individuals belonging to the four different species of the complex of species of Balkan mole rats Spalax leucodon captured at four different localities in Yugoslavia. All populations were ...
New structures of MHC molecules have significantly improved our understanding of molecular recognition in cellular immunology. Highlights include the first structure of a class II MHC molecule, complexed with a viral peptide and with a bacterial superantigen. A structure of an MHC-like Fc receptor is...
Diploid organisms have two copies of each autosomal chromosome, each of which carries genetic variation. The process of determining whether a known variant allele is located on none, one or both of these copies is referred to as genotyping. Variant genotyping is an essential step in genetic studi...
bottom panel shows a heatmap, in which each row represents a gene that matches the terminal sites with the NAP-seq-NGS read exactly, and each column represents the expression values of genes at a specific distance. expr, expression value.gNumber of coincidences between the 5’-start sites in...
while high-occupancy sites tend to associate with repressive histone marks; that genes in the vicinity of low-occupancy sites have a greater expression in CD4+ T cells relative to the genes near high-occupancy sites; and that genes located between two high-occupancy sites tend to be co-regulat...
while high-occupancy sites tend to associate with repressive histone marks; that genes in the vicinity of low-occupancy sites have a greater expression in CD4+ T cells relative to the genes near high-occupancy sites; and that genes located between two high-occupancy sites tend to be co-regulat...
New structures of MHC molecules have significantly improved our understanding of molecular recognition in cellular immunology. Highlights include the first structure of a class II MHC molecule, complexed with a viral peptide and with a bacterial superantigen. A structure of an MHC-like Fc receptor is...
The major histocompatibility complex (MHC) is composed of a set of linked genes encoding proteins involved in the host's immune response1. A subset of these proteins are the classical transplantation antigens, which are responsible for rapid allograft rejection and are involved in the associative ...