MHC Class II基因有许多别称,如HLA-D region(人类白细胞抗原-D区域)、Ia gene(Ia基因)等。这些别称来源于基因所在的位置和功能。在我国,MHC Class II基因的研究已取得丰硕成果,为免疫学、遗传学等领域的发展做出了巨大贡献。 【五、总结】 MHC Class II基因作为免疫系统中的关键分子,其研究不仅在基础科学领域具...
MHC class II A gene in the channel catfish( Ictalurus punctatus ) Dev Comp Immunol. 2000; 24 (6/7):609–622.Godwin UB, Flores M, Quiniou S, Wilson MR, Miller NW, Clem LW, McConnell TJ. MHC class II A genes in the channel catfish (Ictalurus punctatus). Dev Comp Immunol. 2000 ...
Class Monoclonal Type Antibody Full Name histocompatibility 2, class II antigen A, alpha Synonyms Aalpha, H 2Aa, H2Aa, H2-Aa, Ia 1, Ia1, IAalpha, MHC Class II GenBank Accession Number BC031711 Gene Symbol MHC Class II Gene ID (NCBI) 14960 RRID AB_2883788 Conjugate FITC Plus Fluoresc...
Description: The M5/114.15.2 monoclonal antibody reacts with the mouse major histocompatibility complex class II, both I-A and I-E subregion-encoded glycoproteins (I-A b, I-A d, I-A q, I-E d, I-E k, not I-A f, I-A k, or I-A s). It detects a poly...
STAT1 瓜氨酸化促进 STAT1-PIAS1 相互作用和 MHC class II 减少 作者接下来探讨了 PAD4 介导的 STAT1 瓜氨酸化是否以及如何负向调节 MHC II 类编码基因的转录。PAD4 缺失会增强 STAT1 信号转导,从而增强 MHC II 类基因的表达和功能(图 3)。因此,作者推测 STAT1 瓜氨酸化会抑制 STAT1 的转录活性。PIAS1(活...
dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends an...
21.2.2MHC Class II TheMHCclass II molecule (MHCII) is composed of twopolypeptide chains, α and β, each of which traverses the cell membrane and associates to form aheterodimercontaining two conserved immunoglobulin-like domains proximal to the cell membrane (α2β2) and two polymorphic domai...
This complex gene-expression profile is controlled almost exclusively by a single master regulatory factor, which is known as the class II transactivator. As we discuss here, differential activation of the three independent promoters that drive expression of the gene encoding the class II ...
典型MHC基因的多态性较普通的多态性基因复杂得多(如与ABO血型抗原基因比较)多态性变异较为集中于HLA分子与抗原肽结合部位的结构域许多多态性变异基因并未发现其对应的表达分子,PolymorphisminMHCClassIgenes,D.uk/HIG/index.htmlOctober2003,998alleles(657inJuly2000),PolymorphisminMHCClassIIgenes,D.uk/HIG/index.ht...