In humans, the MHC class I genes consist of the classical loci of HLA-A, -B, and -C, and the nonclassical loci HLA-E, -F, and -G. In Platyrrhini species, few MHC class I genes have been described so far and were classified as MHC-E, MHC-F, and MHC-G, with MHC-G ...
MHC class I genes in a New World primate, the cotton-top tamarin ( Saguinus oedipus ), have evolved by an active process of loci turnover I. Watkins, 1999 MHC class I genes in a New World primate, the cotton-top tamarin (Saguinus oedipus), have evolved by an active process of loci ...
Amplification of the protective effect can be achieved by combination of syngeneic and allogeneic MHC class I genes. Studying the mechanisms involved in MHC class I suppression in tumor cells, we found that changes in H-2 promoter activity were the cause of low expression. Proteins that might ...
1996. The MHC class I genes of the rhesus monkey: different evolutionary histories of MHC class I and II genes in primates. J. Immunol. 156:4656.Boyson JE, Shufflebotham C, Cadavid LF, Urvater JA, Knapp LA, Hughes AL, Watkins DI. 1996. The MHC class I genes of the rhesus monkey....
MHC class I molecules are composed of a polymorphic chain and a non-polymorphic invariant β chain (B2M) linked by a noncovalent interaction. MHC class I genes are categorized into classical (MHC class Ia) (HLA-A, -B, -C, see Glossary) or nonclassical (MHC class Ib) (HLA-E, -F, -...
We cloned, sequenced and transfected the MHC class I genes from three other species of bone-chimeric primates (the saddle-backed tamarin, S. fuscicollis; the common marmoset, Callithrix jacehus; and the golden-headed lion tamarin, Leontopithecus rosalia) and a single species of a non-bone marro...
On the biological front, despite the fact that both MICA and HLA class I genes and molecules have a similar and unique tri-dimensional structure, major differences exist in their respective functions, for example HLA class I require both the β2-microglobulin and an endogenously derived peptide ...
MHC class I molecules are expressed by all nucleated cells of the body. They bind small fragments of protein from inside a cell and present these at the cell surface. CD8-positive T cells and NK cells can detect infected or damaged cells by scanning MHC class I molecules. Latest Research ...
典型MHC基因的多态性较普通的多态性基因复杂得多(如与ABO血型抗原基因比较)多态性变异较为集中于HLA分子与抗原肽结合部位的结构域许多多态性变异基因并未发现其对应的表达分子,PolymorphisminMHCClassIgenes,D.uk/HIG/index.htmlOctober2003,998alleles(657inJuly2000),PolymorphisminMHCClassIIgenes,D.uk/HIG/index.ht...
The MHC class I genes of the New World primate, the cotton-top tamarin (Saguinus oedipus), are an exception to the high polymorphism and variability displayed by this multigene family. We report the isolation of the first two processed pseudogenes from the MHC region in primates. These two MH...