当前领域的主流理论认为促进MHC-I抗原递呈途径的关键基因(比如B2M, TAP1/2, JAK等等)的突变或者缺失是绝大部分肿瘤MHC-I抗原呈递下调的主要原因。但是这些基因的突变频率非常低,基于这些机制的潜在疗法 (比如gene therapy)对于肿瘤治疗实用性也不高,所以针对MHC-I抗原递呈途径的策略在肿瘤免疫领域一直没有得到显著的...
英文名称: Human soluble MHC-I chain related gene A(sMICA)ELISA kit 用途: 科研试验 产地: 上海 品牌: 佰利莱生物 包装规格: 96T/48T 标记物: HRP标记物 样本: 血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法: 酶联免疫法 应用: 定性检测/定量检测/酶活检测 检测限: 0- 货号:...
英文名称: soluble major histocompatibility complex class I chain-related gene A 用途: 科研 产地: 上海 品牌: 白益 包装规格: 48T 标记物: HRP标记物 样本: 血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法: 酶联免疫法 应用: 详见说明书 检测限: 详见说明书 货号: BY-HS11011 是否...
Vaccination with peptides presented by LUAD in vivo induced CD8+ T cell responses in naive mice and tumour-bearing mice. Many peptides specific to LUAD, including immunogenic peptides, exhibited minimal expression of the cognate mRNA, which prompts the reconsideration of antigen prediction pipelines...
但是这些基因的突变频率非常低,基于这些机制的潜在疗法(比如gene therapy)对于肿瘤治疗实用性也不高,所以针对MHC-I抗原递呈途径的策略在肿瘤免疫领域一直没有得到显著的应用。 2023年8月8日,纽约大学 (NYU) 格罗斯曼医学院王俊教授、Iannis Aifantis教授作为共同通讯作者(Aifantis教授课题组博士后陈旭峰和王俊教授课题组...
通过使用一系列包含从人CD274Gene克隆的启动子片段的荧光素酶报告基因,我们发现干扰素γ(已知能激活PD-L1转录)在SU86.86和SW1990细胞中都能诱导启动子报告基因的活性,这一活性可被GR基因敲除(图1N和补充图1K)所抑制。此外,GR的沉默和地塞...
Comparisons of MHC gene content and diversity among closely related species can provide insights into the evolutionary mechanisms shaping immune system variation. After chimpanzees and bonobos, gorillas are humans' closest living relatives; but in contrast, relatively little is known about the structure ...
and its ablation enhanced MHC-I AP and reduced tumor growth in a CD8+ T cell-dependent manner. Mechanistically, SUSD6 forms a trimolecular complex with TMEM127 and MHC-I, which recruitsWWP2for MHC-I ubiquitination and lysosomal degradation. Together with the SUSD6/TMEM127/WWP2 gene signature...
IFN-gamma up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-gamma can induce multiple gene expressions that a... F Zhou - 《International Reviews of Immunology》 被引量: 188发表: 2009年 Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted...
All of the New World primate classical MHC class I genes, including those of A.trivirqatus, were related to the human non-clasical HLA-G gene. The S.fuscicollis MHC class I genes were indistinguishable from those of S.oedipus. Surprisingly, the MHC class I genes of C.jacchus were only...