人类的MHC-II也被称之为HLA-II，包含有三个可以直接给CD4+T细胞递呈抗原的等位基因，也就是HLA-DR (包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP (包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ (包括 HLA-DQA1和 HLA-DQB1 genes)。而MHC-II分子的多态性，其结合区域的高度多样性...
人类的MHC-II也被称之为HLA-II,包含有三个可以直接给CD4+T细胞递呈抗原的等位基因,也就是HLA-DR(包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP(包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ(包括 HLA-DQA1和 HLA-DQB1 genes)。...
小斑猫鲨 MHC IIβ基因的等位基因共分离与单倍型多样性研究:揭开鲨鱼免疫遗传的神秘面纱 《Immunogenetics》:Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark Scyliorhinus canicula 编辑推荐: 为探究鲨鱼主要组织相容性复合体(MHC)IIβ基因的遗传规律,研究人员以小斑猫...
While MHC-II genes are typically expressed by professional antigen-presenting cells, they are also expressed in tumor cells, potentially facilitating antitumor immune responses. To understand the role of MHC-II-expressing tumor cells, we analyzed triple-negative breast cancer (TN...
The first threeare subunits of RFX, a ubiquitously expressed factor that binds to the promoters of all MHC II genes. CIITA isthe master control factor for MHC II expression. The highly regulated expression pattern of CIITA ultimatelydictates the cell type specificity , induction and level of MHC...
MHC II Monomorphic is part of major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-perf...
MHC II Monomorphic is part of major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through hi...
Immunogenic neoepitope load per sample was calculated as the unique number of mutant peptides regardless of HLA genes. Neoepitope immunogenicity score per mutation was calculated as the mean or maximum of all pMHC pairs derived from the mutation. Extended Data Fig. 2 PR curve of DeepNeo models....
27、marelated gene 1 to activate transcription of major histocompatibility complex class II genesJ. Mol Cell Biol, 2002, 22(14): 5019-5026.8 Kanazawa S, Okamoto T, Peterlin BM. Tat competes with CIITA for the binding to PTEFb and blocks the expression of MHC class II genes in HIV infecti...
Allelic variation in MHCII genes creates many different peptide-binding preferences among different MHC proteins, resulting in different repertoires of bound peptides. Structures of MHCII proteins in complex with the MHC-associated invariant chain chaperone and the peptide exchange catalyst DM have ...