人类的MHC-II也被称之为HLA-II，包含有三个可以直接给CD4+T细胞递呈抗原的等位基因，也就是HLA-DR (包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP (包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ (包括 HLA-DQA1和 HLA-DQB1 genes)。而MHC-II分子的多态性，其结合区域的高度多样性...
人类的MHC-II也被称之为HLA-II,包含有三个可以直接给CD4+T细胞递呈抗原的等位基因,也就是HLA-DR(包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP(包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ(包括 HLA-DQA1和 HLA-DQB1 genes)。...
Mach B, Steimle V, Martinez-Soria E, Reith W. Regulation of MHC class II genes: lessons from a disease. Ann Rev Immunol 1996; 14: 301±331.Mach, B., V. Steimle, E. Martinez-Soria, and W. Reith. 1996. Regulation of MHC class II genes: lessons from a disease. Annu. Rev. ...
人类的MHC-II也被称之为HLA-II,包含有三个可以直接给CD4+T细胞递呈抗原的等位基因,也就是HLA-DR (包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP (包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ (包括 HLA-DQA1和 HLA-DQB1 genes)。而MHC-II分子的多态性,其结合区域的高度多样性以及...
Immunogenic neoepitope load per sample was calculated as the unique number of mutant peptides regardless of HLA genes. Neoepitope immunogenicity score per mutation was calculated as the mean or maximum of all pMHC pairs derived from the mutation. Extended Data Fig. 2 PR curve of DeepNeo models....
The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 ...
Our results suggest that the genes responsible for the outcome are unknown, so far, and those HLA associations reported in several ethnic groups may represent genetic markers in nonrandom association with the responsible genes involved in determining viral clearance or chronic viremia following HCV ...
Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina).Northern pig-tailed macaqueMacaca leoninaMHC class IIAIDS modelTo find new HIV-1 inhibitors with excellent activities against not only wild-type HIV-1 strans but also...
PROBLEM: Major histocompatibility complex (MHC) class II molecule expression is specifically suppressed on fetal trophoblasts, even in response to interferon (IFN)-γ, a potent inducer of MHC class II genes. The suppression of class II induction has been suggested to play a role in preventing re...
被引量: 2 摘要: The present invention relates to a novel transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.收藏...