人类的MHC-II也被称之为HLA-II,包含有三个可以直接给CD4+T细胞递呈抗原的等位基因,也就是HLA-DR(包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP(包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ(包括 HLA-DQA1和 HLA-DQB1 genes)。...
人类的MHC-II也被称之为HLA-II，包含有三个可以直接给CD4+T细胞递呈抗原的等位基因，也就是HLA-DR (包括HLA- DRA1和 HLA-DRB1, -DRB3, -DRB4, 以及 -DRB5); HLA-DP (包括HLA-DPA1 和 HLA-DPB1); 和HLA-DQ (包括 HLA-DQA1和 HLA-DQB1 genes)。而MHC-II分子的多态性，其结合区域的高度多样性...
Luetkemeier ES, Malhi RS, Beever JE, Schook LB (2009) Diver- sification of porcine MHC class II genes: evidence for selec- tive advantage. Immunogenetics 61:119-129. doi:10.1007/ s00251-008-0348-5LUETKEMEIER E S,MALHI R S,BEEVER J E. Diversification of porcine MHC class Ⅱ genes:...
Bontrop RE. 1997. MHC class II genes of nonhuman primates. In: Molecular biologyBontrop, R. E: MHC class II genes of nonhuman primates. In: Molecular biology and evolution of blood group and MHC antigens in primates. Eds Blancher, A. Klein, J & W. W. Socha, Springer-Verlag, ...
27、marelated gene 1 to activate transcription of major histocompatibility complex class II genesJ. Mol Cell Biol, 2002, 22(14): 5019-5026.8 Kanazawa S, Okamoto T, Peterlin BM. Tat competes with CIITA for the binding to PTEFb and blocks the expression of MHC class II genes in HIV infecti...
2.1CIITA: The Master Transcriptional Regulator of MHC Class II Genes MHCclass II molecules are heterodimericglycoproteinscomposed of a α and aβ chain, which are constitutively displayed at the surface of professional antigen-presenting cells (APCs) such as dendritic cells (DCs), macrophages, and ...
Immunogenic neoepitope load per sample was calculated as the unique number of mutant peptides regardless of HLA genes. Neoepitope immunogenicity score per mutation was calculated as the mean or maximum of all pMHC pairs derived from the mutation. Extended Data Fig. 2 PR curve of DeepNeo models....
典型MHC基因的多态性较普通的多态性基因复杂得多(如与ABO血型抗原基因比较)多态性变异较为集中于HLA分子与抗原肽结合部位的结构域许多多态性变异基因并未发现其对应的表达分子,PolymorphisminMHCClassIgenes,D.uk/HIG/index.htmlOctober2003,998alleles(657inJuly2000),PolymorphisminMHCClassIIgenes,D.uk/HIG/index.ht...
The highly regulated pattern of expression of the gene encoding CIITA dictates where, when and to what level MHC class II genes are expressed. Transcription of the gene encoding CIITA is controlled by a large regulatory region that contains three independent promoters (pI, pIII and pIV). These ...
编码HLA抗原的基因由多基因座组成,称为HLA基因复合体,位于第6对染色体短臂(6p21.3),共3400kb,其中I类基因区域约800kb,II类约2000kb,III类1100kb(图2-6)。通过大规模基因测序,目前已发现在此区域约有224个基因,其中至少128个基因表达,多数基因尚不知功能。 Fig 2-6 Genomic map of MHC genes of human (...